Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9179395 | 0.89 | HTR1A (0.60) | HTR1AALDH1A1LMNACYP3A4ALOX12 | |
| SCHEMBL9183283 | 0.86 | HTR1A (0.56) | HTR1AALDH1A1LMNACYP3A4ALOX12 | |
| SCHEMBL9467135 | 0.84 | HTR1A (0.51) | HTR1AALDH1A1LMNACYP3A4ALOX12 | |
| SCHEMBL9178367 | 0.81 | ALDH1A1 (0.64) | HTR1AALDH1A1LMNACYP3A4ALOX12 | |
| SCHEMBL9173712 | 0.81 | HTR1A (0.64) | HTR1AALDH1A1LMNACYP3A4ALOX12 | |
| SCHEMBL9183289 | 0.80 | PREP (0.43) | ALDH1A1LMNA | |
| SCHEMBL9181634 | 0.79 | HTR1A (0.53) | HTR1AALDH1A1LMNACYP3A4ALOX12 | |
| SCHEMBL9175474 | 0.79 | HTR1A (0.65) | HTR1A | |
| SCHEMBL9179406 | 0.78 | HTR1A (0.67) | HTR1AALDH1A1LMNACYP3A4ALOX12 | |
| SCHEMBL9466374 | 0.78 | HTR1A (0.51) | HTR1AALDH1A1LMNACYP3A4ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490772-B1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-07-26 | — | — | EP | disclosed |
| US-5194437-A | Substituted with oxygen containing heterocycle, central nervous system disorders, neuroendocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-03-16 | — | — | US | disclosed |
| EP-0490772-A1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-06-17 | — | — | EP | disclosed |