Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9178455 | 1.00 | TP53 (0.56) | TP53MAPK10DHODHRAB9AALDH1A1 | |
| SCHEMBL9178670 | 0.86 | DHODH (0.52) | DHODHRAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL9397486 | 0.86 | DHODH (0.52) | DHODHRAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL9178618 | 0.86 | MEN1 (0.59) | TP53DHODHRAB9AALDH1A1MEN1 | |
| SCHEMBL9178625 | 0.86 | MEN1 (0.59) | TP53DHODHRAB9AALDH1A1MEN1 | |
| SCHEMBL9178663 | 0.86 | DHODH (0.52) | DHODHRAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL9182765 | 0.86 | DHODH (0.52) | TP53MAPK10DHODHALDH1A1MEN1 | |
| SCHEMBL9182762 | 0.86 | DHODH (0.52) | TP53MAPK10DHODHALDH1A1MEN1 | |
| SCHEMBL9397490 | 0.86 | DHODH (0.52) | DHODHRAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL5914911 | 0.85 | DHODH (0.71) | TP53MAPK10DHODHRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0551230-B1 | Cyano-2-hydroxy-3-enamide derivatives, process for their preparation, their use as drugs, pharmaceutical compositions containing them and intermediates obtained | ROUSSEL UCLAF (FR) | 1995-07-19 | — | — | EP | disclosed |
| US-5308865-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1994-05-03 | — | — | US | disclosed |
| CN-1079216-A | New enamides and method for making thereof and application | ROUSSEL UCLAF (FR) | 1993-12-08 | — | — | CN | disclosed |
| EP-0551230-A1 | Cyano-2-hydroxy-3-enamide derivatives, process for their preparation, their use as drugs, pharmaceutical compositions containing them and intermediates obtained | ROUSSEL UCLAF (FR) | 1993-07-14 | — | — | EP | disclosed |