Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | IL18 | Q14116 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9397490 | 1.00 | DHODH (0.52) | DHODHMAPTLMNATSHRHTT | |
| SCHEMBL9178455 | 0.86 | TP53 (0.56) | DHODHMAPTLMNAHTTMEN1 | |
| SCHEMBL9178663 | 0.86 | DHODH (0.52) | DHODHMAPTLMNATSHRMEN1 | |
| SCHEMBL9178618 | 0.86 | MEN1 (0.59) | DHODHMAPTLMNATSHRHTT | |
| SCHEMBL9182765 | 0.86 | DHODH (0.52) | DHODHTSHRMEN1KMT2APKM | |
| SCHEMBL9178670 | 0.86 | DHODH (0.52) | DHODHMAPTLMNATSHRMEN1 | |
| SCHEMBL9178461 | 0.86 | TP53 (0.56) | DHODHMAPTLMNAHTTMEN1 | |
| SCHEMBL9182762 | 0.86 | DHODH (0.52) | DHODHTSHRMEN1KMT2APKM | |
| SCHEMBL9178625 | 0.86 | MEN1 (0.59) | DHODHMAPTLMNATSHRHTT | |
| SCHEMBL201980 | 0.83 | RXFP1 (0.57) | MAPTLMNATSHRHTTNLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5308865-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1994-05-03 | — | — | US | disclosed |
| EP-0551230-A1 | Cyano-2-hydroxy-3-enamide derivatives, process for their preparation, their use as drugs, pharmaceutical compositions containing them and intermediates obtained | ROUSSEL UCLAF (FR) | 1993-07-14 | — | — | EP | disclosed |