Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9178670 | 1.00 | DHODH (0.52) | DHODHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL9397490 | 0.86 | DHODH (0.52) | DHODHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL9178455 | 0.86 | TP53 (0.56) | DHODHMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9178618 | 0.86 | MEN1 (0.59) | DHODHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL9182762 | 0.86 | DHODH (0.52) | DHODHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL9178461 | 0.86 | TP53 (0.56) | DHODHMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9178625 | 0.86 | MEN1 (0.59) | DHODHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL9182765 | 0.86 | DHODH (0.52) | DHODHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL9397486 | 0.86 | DHODH (0.52) | DHODHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL5914890 | 0.85 | DHODH (0.70) | DHODHMEN1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0551230-B1 | Cyano-2-hydroxy-3-enamide derivatives, process for their preparation, their use as drugs, pharmaceutical compositions containing them and intermediates obtained | ROUSSEL UCLAF (FR) | 1995-07-19 | — | — | EP | claimed |
| US-5308865-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1994-05-03 | — | — | US | claimed |
| EP-0551230-A1 | Cyano-2-hydroxy-3-enamide derivatives, process for their preparation, their use as drugs, pharmaceutical compositions containing them and intermediates obtained | ROUSSEL UCLAF (FR) | 1993-07-14 | — | — | EP | claimed |
| EP-0551230-B1 | Cyano-2-hydroxy-3-enamide derivatives, process for their preparation, their use as drugs, pharmaceutical compositions containing them and intermediates obtained | ROUSSEL UCLAF (FR) | 1995-07-19 | — | — | EP | disclosed |
| US-5308865-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1994-05-03 | — | — | US | disclosed |
| EP-0551230-A1 | Cyano-2-hydroxy-3-enamide derivatives, process for their preparation, their use as drugs, pharmaceutical compositions containing them and intermediates obtained | ROUSSEL UCLAF (FR) | 1993-07-14 | — | — | EP | disclosed |