Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9174188 | 0.95 | POLB (0.56) | SMN1; SMN2RAB9ANPC1HTTPOLB | |
| SCHEMBL9179564 | 0.92 | RAB9A (0.46) | SMN1; SMN2RAB9ANPC1HTTPOLB | |
| SCHEMBL9175479 | 0.87 | MAPT (0.45) | SMN1; SMN2RAB9ANPC1HTTPOLB | |
| SCHEMBL9182119 | 0.85 | POLB (0.58) | SMN1; SMN2RAB9ANPC1HTTPOLB | |
| SCHEMBL9175907 | 0.85 | POLB (0.58) | SMN1; SMN2RAB9ANPC1HTTPOLB | |
| SCHEMBL9178041 | 0.83 | NPC1 (0.53) | SMN1; SMN2RAB9ANPC1HTTMAPT | |
| SCHEMBL9178393 | 0.78 | TACR1 (0.57) | SMN1; SMN2RAB9ANPC1HTTPOLB | |
| SCHEMBL27193044 | 0.72 | RAB9A (0.77) | SMN1; SMN2RAB9ANPC1HTTPOLB | |
| SCHEMBL9260108 | 0.70 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9ANPC1HTTMAPT | |
| SCHEMBL9278296 | 0.70 | POLB (0.52) | SMN1; SMN2RAB9ANPC1HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481383-B1 | Heterocyclic amine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5300646-A | Intermediates for acylcoenzyme A:cholesterol acyltransferase inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5198462-A | Acyl Coenzyme A:Cholesterol Transferase Inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-03-30 | — | — | US | disclosed |
| EP-0481383-A1 | Heterocyclic amine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-04-22 | — | — | EP | disclosed |