Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9179438 | 0.86 | TACR1 (0.46) | TACR1MAPTNPSR1HTTSMN1; SMN2 | |
| SCHEMBL9177097 | 0.86 | TACR1 (0.48) | TACR1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9179860 | 0.85 | RAB9A (0.50) | MAPTNPSR1HTTSMN1; SMN2NPC1 | |
| SCHEMBL8947989 | 0.79 | THRB (0.51) | TACR1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9177141 | 0.79 | TACR1 (0.50) | TACR1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8936601 | 0.79 | TACR1 (0.70) | TACR1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL9178705 | 0.78 | SMN1; SMN2 (0.51) | MAPTHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9174188 | 0.73 | POLB (0.56) | MAPTHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8936542 | 0.73 | TACR1 (0.86) | TACR1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL13845573 | 0.72 | MAPT (0.88) | MAPTNPSR1HTTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481383-B1 | Heterocyclic amine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5300646-A | Intermediates for acylcoenzyme A:cholesterol acyltransferase inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5198462-A | Acyl Coenzyme A:Cholesterol Transferase Inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-03-30 | — | — | US | disclosed |
| EP-0481383-A1 | Heterocyclic amine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-04-22 | — | — | EP | disclosed |