Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASGR1 | P07306 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3616201 | 1.00 | ASGR1 (0.41) | ASGR1HSD11B1SSTR4NFKB1NFKB2 | |
| SCHEMBL31633856 | 1.00 | ASGR1 (0.41) | ASGR1HSD11B1SSTR4NFKB1NFKB2 | |
| SCHEMBL5438279 | 0.83 | ASGR1 (0.39) | ASGR1HSD11B1 | |
| SCHEMBL785468 | 0.81 | HSD11B1 (0.41) | ASGR1HSD11B1NFKB1NFKB2RELA | |
| Hydrochloric Acid SCHEMBL2401902 | 0.80 | HSD11B1 (0.40) | ASGR1HSD11B1NFKB1NFKB2RELA | |
| SCHEMBL22236163 | 0.79 | CHRNB2 (0.37) | SSTR4 | |
| SCHEMBL14428327 | 0.79 | HSD11B1 (0.42) | ASGR1HSD11B1NFKB1NFKB2RELA | |
| SCHEMBL2092023 | 0.78 | HSD11B1 (0.35) | ASGR1HSD11B1SSTR4 | |
| SCHEMBL25282846 | 0.77 | ASGR1 (0.37) | ASGR1HSD11B1 | |
| SCHEMBL22138095 | 0.77 | ASGR1 (0.37) | ASGR1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5391763-A | 3-aza-bicyclo[3.1.0]hexanes which are intermediates for anti-bacterial azabicyclo quinolone carboxylic acids | PFIZER INC. (US) | 1995-02-21 | — | — | US | disclosed |
| US-5266569-A | Azatricyclo carboxylic acids useful as anti-bacterial agents | PFIZER INC. (US) | 1993-11-30 | — | — | US | disclosed |
| US-5229396-A | Anti-bacterial azabicyclo quinolone carboxylic acids | PFIZER INC. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5164402-A | Bactericides | PFIZER INC (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0413455-A2 | Azabicyclo quinolone carboxylic acids | PFIZER INC. (US) | 1991-02-20 | — | — | EP | disclosed |