SCHEMBL9180286

SCHEMBL9180286

CC(Cl)OC(=O)OCC1CCC1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC1A3 P43003 6/20 0.40
SLC1A2 P43004 6/20 0.40
SLC1A1 P43005 6/20 0.40
LMNA P02545 1/20 0.39
CTSK P43235 3/20 0.33
PARP15 Q460N3 1/20 0.32
PARP10 Q53GL7 1/20 0.32
PARP2 Q9UGN5 1/20 0.32
ALOX5 P09917 1/20 0.32
THRA P10827 1/20 0.31
THRB P10828 1/20 0.31
JMJD6 Q6NYC1 1/20 0.31
CTSL P07711 1/20 0.31
CTSB P07858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9182331 0.82 SLC1A3 (0.40) SLC1A3SLC1A2SLC1A1LMNACTSK
SCHEMBL18072127 0.80 LMNA (0.47) SLC1A3SLC1A2SLC1A1LMNACTSK
SCHEMBL698776 0.79 LMNA (0.44) SLC1A3SLC1A2SLC1A1LMNAPARP15
SCHEMBL4480821 0.78 EPHX1 (0.38) CTSKCTSLCTSB
SCHEMBL25381860 0.78 LMNA (0.50) SLC1A3SLC1A2SLC1A1LMNAPARP15
SCHEMBL6889754 0.77 LMNA (0.45) SLC1A3SLC1A2SLC1A1LMNACTSK
SCHEMBL18069591 0.77 LMNA (0.45) SLC1A3SLC1A2SLC1A1LMNACTSK
SCHEMBL27101966 0.76 RAB9A (0.41) SLC1A3SLC1A2SLC1A1LMNACTSK
SCHEMBL22558157 0.76 APP (0.32)
SCHEMBL698000 0.75 LMNA (0.48) SLC1A3SLC1A2SLC1A1LMNACTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1144222-A New cephem compounds FUJISAWA PHARMACEUTICAL CO (JP) 1997-03-05 CN disclosed
EP-0665847-A1 CEPHEM COMPOUNDS, AND THEIR PHARMACEUTICAL COMPOSITIONS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1995-08-09 EP disclosed
WO-1994010177-A1 CEPHEM COMPOUNDS, AND THEIR PHARMACEUTICAL COMPOSITIONS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 WO disclosed