Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12894890 | 0.87 | SLC6A4 (0.51) | GAAHSD11B1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8484148 | 0.85 | GAA (0.50) | GAASLC6A4SLC6A2SLC6A3OPRM1 | |
| SCHEMBL3533236 | 0.85 | GAA (0.47) | GAAHSD11B1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8368989 | 0.85 | OPRM1 (0.62) | GAASLC6A4SLC6A2SLC6A3OPRM1 | |
| SCHEMBL3545681 | 0.85 | GAA (0.47) | GAAHSD11B1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7931833 | 0.84 | GAA (0.51) | GAAHSD11B1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL3542659 | 0.84 | GAA (0.48) | GAAHSD11B1OPRM1SMN1; SMN2NPSR1 | |
| SCHEMBL8485288 | 0.84 | GAA (0.51) | GAASLC6A4SLC6A2SLC6A3OPRM1 | |
| SCHEMBL434932 | 0.83 | GAA (0.48) | GAASLC6A4SLC6A2SLC6A3OPRM1 | |
| SCHEMBL25288068 | 0.82 | GAA (0.62) | GAASLC6A4OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490772-B1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-07-26 | — | — | EP | disclosed |