Bromide

Bromide

SCHEMBL9181732

Br.CN(C)Cc1ccccc1CCOc1ccccc1

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 known ✓ P31645 5/20 0.53
SLC6A2 known ✓ P23975 3/20 0.53
SLC6A3 known ✓ Q01959 2/20 0.46
HTR1D known ✓ P28221 1/20 0.42
HTR1B known ✓ P28222 1/20 0.42
LTA4H P09960 2/20 0.49
KCNA3 P22001 1/20 0.45
LSS P48449 1/20 0.44
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
HTR2A P28223 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9185533 0.98 SLC6A4 (0.54) SLC6A4SLC6A2LTA4HSLC6A3KCNA3
SCHEMBL9180605 0.90 SLC6A2 (0.53) SLC6A4SLC6A2LTA4HSLC6A3KCNA3
Hydrochloric Acid SCHEMBL9179819 0.88 SLC6A2 (0.51) SLC6A4SLC6A2LTA4HSLC6A3KCNA3
SCHEMBL9183113 0.81 LTA4H (0.46) LTA4HKCNA3
SCHEMBL9539239 0.79 KCNA3 (0.45) LTA4HKCNA3HDAC3HDAC4HDAC1
SCHEMBL9182367 0.75 LTA4H (0.50) SLC6A4SLC6A2LTA4HSLC6A3HTR2A
SCHEMBL9179867 0.75 SLC6A4 (0.45) SLC6A4SLC6A2SLC6A3HTR2ATAAR1
SCHEMBL9187372 0.74 KDM4E (0.50) SLC6A4SLC6A2LTA4HKCNA3HTR1B
SCHEMBL125255 0.74 ALDH1A1 (0.57) SLC6A4SLC6A2SLC6A3HTR2ATAAR1
SCHEMBL29729780 0.74 ALDH1A1 (0.57) SLC6A4SLC6A2SLC6A3HTR2ATAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0549773-B1 ETHER-CONTAINING QUATERNARY AMMONIUM SALTS EASTMAN KODAK CO (US) 1995-07-05 EP claimed
EP-0549773-A1 ETHER-CONTAINING QUATERNARY AMMONIUM SALTS. EASTMAN KODAK CO (US) 1993-07-07 EP claimed
WO-1993002040-A1 ETHER-CONTAINING QUATERNARY AMMONIUM SALTS EASTMAN KODAK COMPANY (US) 1993-02-04 WO claimed
US-5126225-A Lower fusion temperatures, improved adhesion to paper EASTMAN KODAK COMPANY (US) 1992-06-30 US claimed
EP-0549773-B1 ETHER-CONTAINING QUATERNARY AMMONIUM SALTS EASTMAN KODAK CO (US) 1995-07-05 EP disclosed
EP-0549773-A1 ETHER-CONTAINING QUATERNARY AMMONIUM SALTS. EASTMAN KODAK CO (US) 1993-07-07 EP disclosed
WO-1993002040-A1 ETHER-CONTAINING QUATERNARY AMMONIUM SALTS EASTMAN KODAK COMPANY (US) 1993-02-04 WO disclosed
US-5126225-A Lower fusion temperatures, improved adhesion to paper EASTMAN KODAK COMPANY (US) 1992-06-30 US disclosed