Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15297794 | 0.74 | NR1H2 (0.54) | NR1H2MAPTNAMPTGPR119USP2 | |
| SCHEMBL8105173 | 0.74 | NR1H2 (0.39) | NR1H2KDM4EMAPTTHRBNAMPT | |
| SCHEMBL2732461 | 0.73 | NR1H2 (0.40) | NR1H2KDM4EMAPTTHRBNAMPT | |
| SCHEMBL24501242 | 0.70 | NR1H2 (0.53) | NR1H2NAMPTGPR119USP2SMN1; SMN2 | |
| SCHEMBL8151168 | 0.70 | GPR119 (0.55) | KDM4EGPR119USP2SMN1; SMN2 | |
| SCHEMBL23207463 | 0.70 | GPR119 (0.49) | NR1H2KDM4EMAPTGPR119 | |
| SCHEMBL19073548 | 0.69 | NR1H2 (0.37) | NR1H2KDM4EMAPTNAMPTPDE4A | |
| SCHEMBL22906686 | 0.69 | NR1H2 (0.51) | NR1H2NAMPTGPR119USP2SMN1; SMN2 | |
| SCHEMBL25845322 | 0.69 | NR1H2 (0.44) | NR1H2KDM4EMAPTTHRBNAMPT | |
| SCHEMBL5112488 | 0.69 | NR1H2 (0.38) | NR1H2MAPTGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666844-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1995-08-16 | — | — | EP | disclosed |