SCHEMBL9184591

SCHEMBL9184591

Clc1ccc(C2CC(c3ccc(-c4ccccc4)cc3)=NN2)cn1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCL12 P48061 1/20 0.44
MAOA P21397 2/20 0.43
MAOB P27338 2/20 0.43
CHRNB2 P17787 2/20 0.43
CHRNA4 P43681 2/20 0.43
ROCK2 O75116 1/20 0.41
EGFR P00533 1/20 0.41
CSF1R P07333 1/20 0.41
PIM1 P11309 1/20 0.41
PRKACA P17612 1/20 0.41
MAPK1 P28482 1/20 0.41
GSK3A P49840 1/20 0.41
GSK3B P49841 1/20 0.41
LIMK1 P53667 1/20 0.41
PRKCD Q05655 1/20 0.41
STK3 Q13188 1/20 0.41
ROCK1 Q13464 1/20 0.41
CDC42BPA Q5VT25 1/20 0.41
BRAF P15056 1/20 0.40
KDR P35968 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9184589 0.97 CHRNB2 (0.45) CXCL12MAOAMAOBCHRNB2CHRNA4
SCHEMBL9184554 0.90 CXCL12 (0.54) CXCL12MAOAMAOBCHRNB2CHRNA4
SCHEMBL9186848 0.89 CXCL12 (0.55) CXCL12MAOAMAOBCHRNB2CHRNA4
SCHEMBL9183559 0.89 BRAF (0.50) CXCL12MAOAMAOBCHRNB2CHRNA4
SCHEMBL9184061 0.88 MAOA (0.45) CXCL12MAOACHRNB2CHRNA4CHRNB4
SCHEMBL9183356 0.87 MAOA (0.50) CXCL12MAOAMAOBCHRNB2CHRNA4
SCHEMBL9182035 0.86 CA1 (0.48) CXCL12MAOACHRNB2CHRNA4CHRNB4
SCHEMBL9182669 0.86 CXCL12 (0.47) CXCL12MAOAMAOBCHRNB2CHRNA4
SCHEMBL9180840 0.83 CXCL12 (0.45) CXCL12MAOAMAOBCHRNB2CHRNA4
SCHEMBL9181027 0.83 CXCL12 (0.53) CXCL12MAOAMAOBBRAFKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5389648-A Insecticidal pyrazolines NIHON BAYER AGROCHEM K.K. (JP) 1995-02-14 US disclosed
EP-0537581-A2 Pyrazolines as insecticides NIHON BAYER AGROCHEM K.K. (JP) 1993-04-21 EP disclosed