Sugi Predict

Sugi Predict / Compounds / SCHEMBL918549

SCHEMBL918549

SCHEMBL918549

CCCCCCCNCCCS(=O)(=O)O

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.56
▸ TSHR P16473 1/20 0.56
▸ CA1 P00915 2/20 0.53
▸ CA2 P00918 2/20 0.53
▸ EPHX2 P34913 1/20 0.53
▸ S1PR2 O95136 5/20 0.52
▸ S1PR4 O95977 5/20 0.52
▸ S1PR1 P21453 5/20 0.52
▸ S1PR3 Q99500 5/20 0.52
▸ S1PR5 Q9H228 1/20 0.52
▸ RELA Q04206 4/20 0.50
▸ PPARA Q07869 2/20 0.47
▸ EPHX1 P07099 4/20 0.46
▸ ADH1B P00325 1/20 0.46
▸ ADH1C P00326 1/20 0.46
▸ ADH1A P07327 1/20 0.46
▸ ADH4 P08319 1/20 0.46
▸ ADH7 P40394 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL917055 1.00 ALDH1A1 (0.56) ALDH1A1TSHRCA1CA2EPHX2
SCHEMBL917570 1.00 ALDH1A1 (0.56) ALDH1A1TSHRCA1CA2EPHX2
SCHEMBL918031 1.00 ALDH1A1 (0.56) ALDH1A1TSHRCA1CA2EPHX2
SCHEMBL917576 1.00 ALDH1A1 (0.56) ALDH1A1TSHRCA1CA2EPHX2
SCHEMBL917965 1.00 ALDH1A1 (0.56) ALDH1A1TSHRCA1CA2EPHX2
SCHEMBL917918 1.00 ALDH1A1 (0.56) ALDH1A1TSHRCA1CA2EPHX2
SCHEMBL917335 1.00 ALDH1A1 (0.56) ALDH1A1TSHRCA1CA2EPHX2
SCHEMBL918208 1.00 ALDH1A1 (0.56) ALDH1A1TSHRCA1CA2EPHX2
SCHEMBL918712 1.00 ALDH1A1 (0.56) ALDH1A1TSHRCA1CA2EPHX2
SCHEMBL1332019 1.00 ALDH1A1 (0.56) ALDH1A1TSHRCA1CA2EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110281951-A1 Compositions and methods for treating amyloidosis BHI LIMITED PARTNERSHIP (CA) 2011-11-17 — — US claimed
JP-4726304-B2 — — 2011-07-20 — — JP claimed
EP-1276483-B1 COMPOSITIONS AND METHODS FOR TREATING AMYLOIDOSIS USING SULPHONATE DERIVATIVES BELLUS HEALTH INT LTD (CH) 2009-09-02 — — EP claimed
US-20090099100-A1 Compositions and methods for treating amyloidosis BELLUS HEALTH (INTERNATIONAL) LIMITED (CH) 2009-04-16 — — US claimed
US-20050048000-A1 Amyloid targeting imaging agents and uses thereof NEUROCHEM (INTERNATIONAL) LIMITED (CH) 2005-03-03 — — US claimed
JP-2003517458-A — — 2003-05-27 — — JP claimed
EP-1303311-A2 AMYLOID TARGETING IMAGING AGENTS AND USES THEREOF Neurochem, Inc. (CA) 2003-04-23 — — EP claimed
EP-1276483-A2 COMPOSITIONS AND METHODS FOR TREATING AMYLOIDOSIS USING SULPHONATE DERIVATIVES QUEEN'S UNIVERSITY AT KINGSTON (CA) 2003-01-22 — — EP claimed
US-20020115717-A1 Amyloid targeting imaging agents and uses thereof NEUROCHEM (INTERNATIONAL) LIMITED (GI) 2002-08-22 — — US claimed
WO-2002007781-A2 AMYLOID TARGETING IMAGING AGENTS AND USES THEREOF NEUROCHEM INC. (CA) 2002-01-31 — — WO claimed
WO-2000064420-A2 COMPOSITIONS AND METHODS FOR TREATING AMYLOIDOSIS USING SULPHONATE DERIVATIVES QUEEN'S UNIVERSITY AT KINGSTON (CA) 2000-11-02 — — WO claimed
US-20140329746-A1 METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES NEUROCHEM (INTERNATIONAL) LIMITED (CH) 2014-11-06 — — US disclosed
US-8835654-B2 Method and compositions for treating amyloid-related diseases BHI LIMITED PARTNERSHIP (CA) 2014-09-16 — — US disclosed
EP-1646659-B1 METHOD FOR THE PREPARATION OF 1,3-PROPANE DISULFONIC ACID COMPOUNDS KIACTA S RL (CH) 2014-05-14 — — EP disclosed
US-20140107027-A1 METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES BHI LIMITED PARTNERSHIP (CA) 2014-04-17 — — US disclosed
EP-1303311-A2 AMYLOID TARGETING IMAGING AGENTS AND USES THEREOF Neurochem, Inc. (CA) 2003-04-23 — — EP disclosed
EP-1276483-A2 COMPOSITIONS AND METHODS FOR TREATING AMYLOIDOSIS USING SULPHONATE DERIVATIVES QUEEN'S UNIVERSITY AT KINGSTON (CA) 2003-01-22 — — EP disclosed
US-20020115717-A1 Amyloid targeting imaging agents and uses thereof NEUROCHEM (INTERNATIONAL) LIMITED (GI) 2002-08-22 — — US disclosed
WO-2002007781-A2 AMYLOID TARGETING IMAGING AGENTS AND USES THEREOF NEUROCHEM INC. (CA) 2002-01-31 — — WO disclosed
WO-2000064420-A2 COMPOSITIONS AND METHODS FOR TREATING AMYLOIDOSIS USING SULPHONATE DERIVATIVES QUEEN'S UNIVERSITY AT KINGSTON (CA) 2000-11-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090099100-A1 Compositions and methods for treating amyloidosis TTR, SNCA, ARSA ALDH1A1 1526/4885TSHR 1739/4885CA1 326/4885
US-20110281951-A1 Compositions and methods for treating amyloidosis TTR, SNCA, ARSA ALDH1A1 1526/4885TSHR 1739/4885CA1 326/4885
US-20050048000-A1 Amyloid targeting imaging agents and uses thereof APP, APBA1, BACE1 ALDH1A1 3305/4885TSHR 4314/4885CA1 720/4885
US-20020115717-A1 Amyloid targeting imaging agents and uses thereof APP, APBA1, BACE1 ALDH1A1 3305/4885TSHR 4314/4885CA1 720/4885
US-20140329746-A1 METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES APP, PSEN1, PSEN2 ALDH1A1 2989/4885TSHR 4779/4885CA1 582/4885
US-20140107027-A1 METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES APP, PSEN1, PSEN2 ALDH1A1 2989/4885TSHR 4779/4885CA1 582/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.