Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 13/20 | 0.54 |
| ▸ | GAA | P10253 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | SNCA | P37840 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.54 |
| ▸ | CYBB | P04839 | 2/20 | 0.54 |
| ▸ | NOX3 | Q9HBY0 | 2/20 | 0.54 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | BCHE | P06276 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9186453 | 0.98 | NOX1 (0.55) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL10889794 | 0.89 | SNCA (0.55) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL11744639 | 0.83 | NOX1 (0.55) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL9185969 | 0.83 | NOX1 (0.55) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL8941201 | 0.83 | NOX1 (0.55) | NOX1GAAMAPTMEN1KMT2A | |
| Phenothiazine SCHEMBL31210233 | 0.81 | NOX1 (0.53) | NOX1GAAMAPTMEN1KMT2A | |
| Phenothiazine SCHEMBL38662173 | 0.81 | NOX1 (0.74) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL561135 | 0.79 | NOX1 (0.51) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL7360175 | 0.78 | TSHR (0.46) | MAPTSNCATDP1BCHEPOLB | |
| Phenothiazine SCHEMBL31210229 | 0.78 | NOX1 (0.68) | NOX1GAAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0451675-B1 | Process for the direct and regioselective functionalization in position 2 of phenothiazine | ZAMBON SPA (IT) | 1995-11-02 | — | — | EP | disclosed |
| US-5089613-A | Sulfonation of N-acylphenothiazine with sulfuric acid, oleum or chlorosulfonic acid then reduciton to mercaptan and S-alkylation | ZAMBON GROUP S.P.A. (IT) | 1992-02-18 | — | — | US | disclosed |
| EP-0451675-A1 | Process for the direct and regioselective functionalization in position 2 of phenothiazine | ZAMBON GROUP S.p.A. (IT) | 1991-10-16 | — | — | EP | disclosed |