Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NT5E | P21589 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9508137 | 0.94 | ALDH1A1 (0.45) | TSHRSMN1; SMN2ALDH1A1HSD17B10TDP1 | |
| SCHEMBL5505299 | 0.80 | TSHR (0.39) | TSHRSMN1; SMN2ALDH1A1HSD17B10TDP1 | |
| SCHEMBL7357401 | 0.80 | TDP1 (0.46) | ALDH1A1HSD17B10TDP1SNCAPOLB | |
| SCHEMBL29945035 | 0.79 | ALDH1A1 (0.44) | TSHRSMN1; SMN2ALDH1A1HSD17B10TDP1 | |
| SCHEMBL10889794 | 0.79 | SNCA (0.55) | TSHRSMN1; SMN2ALDH1A1HSD17B10TDP1 | |
| SCHEMBL9186453 | 0.79 | NOX1 (0.55) | TSHRSMN1; SMN2ALDH1A1HSD17B10TDP1 | |
| SCHEMBL9508903 | 0.78 | HTR6 (0.54) | TSHRSMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL9185974 | 0.78 | NOX1 (0.54) | TSHRSMN1; SMN2ALDH1A1HSD17B10TDP1 | |
| Sulfuric Acid SCHEMBL27489865 | 0.78 | BCHE (0.44) | TSHRSMN1; SMN2TDP1SNCAPOLB | |
| SCHEMBL9511311 | 0.74 | GAA (0.55) | SMN1; SMN2ALDH1A1TDP1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117869-A | FOR TREATING MULTIPLE SCLEROSIS, ATHEROSCLEROTIC PLAQUE RUPTURE, RESTENOSIS, AORTIC ANEURYSM, HEART FAILURE, PERIODONTAL DISEASE, CORNEAL ULCERATION, BURNS, DECUBITAL ULCERS, CHRONIC ULCERS OR WOUNDS, CANCER METASTASIS | WARNER-LAMBERT COMPANY (US) | 2000-09-12 | — | — | US | disclosed |