Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9186359 | 0.89 | KCNH2 (0.46) | KCNH2SIGMAR1CHRM2 | |
| SCHEMBL5565522 | 0.76 | TSHR (0.43) | — | |
| SCHEMBL10651959 | 0.76 | TSHR (0.52) | KCNH2CHRM2 | |
| SCHEMBL10650754 | 0.74 | TSHR (0.50) | KCNH2SIGMAR1CHRM2 | |
| SCHEMBL10652781 | 0.74 | TSHR (0.55) | KCNH2CHRM2 | |
| SCHEMBL10652084 | 0.73 | TSHR (0.48) | KCNH2SIGMAR1CHRM2 | |
| SCHEMBL10650697 | 0.73 | TSHR (0.53) | KCNH2SIGMAR1 | |
| SCHEMBL10649799 | 0.73 | TSHR (0.48) | KCNH2SIGMAR1CHRM2 | |
| SCHEMBL10647428 | 0.71 | TSHR (0.52) | KCNH2SIGMAR1 | |
| SCHEMBL10647345 | 0.71 | TSHR (0.52) | KCNH2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497202-B1 | Polyamine thiols as radioprotective agents | MERRELL DOW PHARMA (US) | 1995-09-13 | — | — | EP | disclosed |
| US-5217964-A | POLYAMINE THIOLS AS RADIOPROTECTIVE AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-08 | — | — | US | disclosed |
| EP-0497202-A1 | Polyamine thiols as radioprotective agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-08-05 | — | — | EP | disclosed |