Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9190295 | 0.89 | KCNH2 (0.44) | KCNH2SIGMAR1CHRM2 | |
| SCHEMBL5565522 | 0.83 | TSHR (0.43) | MEN1KMT2A | |
| SCHEMBL2464780 | 0.74 | TSHR (0.55) | KCNH2MEN1KMT2ACHRM2 | |
| SCHEMBL19771743 | 0.74 | TSHR (0.45) | MEN1KMT2A | |
| SCHEMBL1408147 | 0.73 | MEN1 (0.42) | KDM4EMEN1KMT2A | |
| SCHEMBL10650495 | 0.72 | TSHR (0.59) | KCNH2KDM4EKMT2ACHRM2 | |
| Perchlorate SCHEMBL7244355 | 0.72 | CNR2 (0.43) | KCNH2KDM4ESIGMAR1MEN1KMT2A | |
| SCHEMBL5928136 | 0.71 | OPRM1 (0.42) | KDM4ESIGMAR1MEN1KMT2A | |
| SCHEMBL10651959 | 0.71 | TSHR (0.52) | KCNH2MEN1KMT2ACHRM2 | |
| SCHEMBL8761649 | 0.70 | KMT2A (0.44) | KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497202-B1 | Polyamine thiols as radioprotective agents | MERRELL DOW PHARMA (US) | 1995-09-13 | — | — | EP | disclosed |
| US-5217964-A | POLYAMINE THIOLS AS RADIOPROTECTIVE AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-08 | — | — | US | disclosed |
| EP-0497202-A1 | Polyamine thiols as radioprotective agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-08-05 | — | — | EP | disclosed |