Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.76 |
| ▸ | PPARD | Q03181 | 1/20 | 0.58 |
| ▸ | ADRB3 | P13945 | 14/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 12/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9193546 | 0.90 | ALOX15 (0.61) | ALOX15PPARDADRB3ADRB1ATM | |
| Talibegron SCHEMBL3699503 | 0.87 | ALOX15 (0.97) | ALOX15ADRB3ADRB1KDM4EGAA | |
| Talibegron SCHEMBL328977 | 0.87 | ALOX15 (0.97) | ALOX15ADRB3ADRB1KDM4EGAA | |
| Talibegron SCHEMBL6060362 | 0.87 | ALOX15 (0.97) | ALOX15ADRB3ADRB1KDM4EGAA | |
| SCHEMBL9192021 | 0.87 | ALOX15 (0.76) | ALOX15ADRB3ADRB1 | |
| SCHEMBL9186507 | 0.87 | ALOX15 (0.76) | ALOX15PPARDADRB3ADRB1 | |
| SCHEMBL9192035 | 0.87 | ALOX15 (0.76) | ALOX15PPARDADRB3ADRB1 | |
| Talibegron SCHEMBL1230810 | 0.86 | ALOX15 (1.00) | ALOX15ADRB3ADRB1KDM4EGAA | |
| Talibegron SCHEMBL8976330 | 0.86 | ALOX15 (1.00) | ALOX15ADRB3ADRB1KDM4EGAA | |
| SCHEMBL9188713 | 0.84 | ALOX15 (0.71) | ALOX15ADRB3ADRB1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516350-B1 | 2-Hydroxy-2-phenylethylamine derivatives as beta-3-adrenoceptor agonists | ZENECA LTD (GB) | 1995-09-20 | — | — | EP | claimed |
| EP-0516350-A2 | 2-Hydroxy-2-phenylethylamine derivatives as beta-3-adrenoceptor agonists | ZENECA LIMITED (GB) | 1992-12-02 | — | — | EP | claimed |
| EP-0516350-B1 | 2-Hydroxy-2-phenylethylamine derivatives as beta-3-adrenoceptor agonists | ZENECA LTD (GB) | 1995-09-20 | — | — | EP | disclosed |
| EP-0516350-A2 | 2-Hydroxy-2-phenylethylamine derivatives as beta-3-adrenoceptor agonists | ZENECA LIMITED (GB) | 1992-12-02 | — | — | EP | disclosed |