Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.67 |
| ▸ | ACHE | P22303 | 5/20 | 0.62 |
| ▸ | HTR7 | P34969 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14375216 | 0.83 | HRH3 (0.67) | HRH3ACHE | |
| SCHEMBL3440098 | 0.80 | HRH3 (0.65) | HRH3ALDH1A1KDM4ESMN1; SMN2NCF1 | |
| SCHEMBL3594477 | 0.79 | LMNA (0.61) | HRH3ALDH1A1KDM4ENCF1 | |
| SCHEMBL156202 | 0.79 | HRH3 (0.76) | HRH3ACHEALDH1A1KDM4E | |
| SCHEMBL8252094 | 0.79 | HRH3 (0.76) | HRH3ACHEHTR7ALDH1A1KDM4E | |
| SCHEMBL4010533 | 0.79 | HRH3 (0.69) | HRH3ALDH1A1KDM4ESMN1; SMN2NCF1 | |
| SCHEMBL8275450 | 0.79 | HRH3 (0.76) | HRH3ACHEALDH1A1 | |
| SCHEMBL6227268 | 0.78 | MEN1 (0.68) | KCNA3 | |
| SCHEMBL3861163 | 0.77 | HRH3 (0.73) | HRH3ACHEHTR7ALDH1A1PARP1 | |
| SCHEMBL3004249 | 0.77 | HRH3 (0.73) | HRH3ACHEHTR7ALDH1A1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0393534-B1 | Pharmaceutically active pteridine derivatives | ROEHM GMBH (DE) | 1995-07-12 | — | — | EP | disclosed |
| US-5124326-A | Antiarrhythmic, hypotensive agents; diuretics | ROEHM GMBH CHEMISCHE FABRIK (DE) | 1992-06-23 | — | — | US | disclosed |
| EP-0393534-A2 | Pharmaceutically active pteridine derivatives | RÖHM GMBH (DE) | 1990-10-24 | — | — | EP | disclosed |