SCHEMBL9192569

SCHEMBL9192569

CC(=O)CC(=O)Nc1ccc(C(c2cccc(Cl)c2)n2ccnc2)cc1[N+](=O)[O-]

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 7/20 0.46
CYP26A1 O43174 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C8 P10632 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP24A1 Q07973 1/20 0.46
CYP26B1 Q9NR63 1/20 0.46
ALDH1A1 P00352 4/20 0.40
MAPT P10636 4/20 0.40
THRB P10828 1/20 0.40
PKM P14618 2/20 0.39
POLB P06746 2/20 0.39
MAPK1 P28482 1/20 0.39
NCOA1 Q15788 1/20 0.39
NCOA3 Q9Y6Q9 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
DOT1L Q8TEK3 1/20 0.38
IDO1 P14902 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10580653 0.81 CYP19A1 (0.51) CYP19A1CYP26A1CYP3A4ALDH1A1MAPT
SCHEMBL9198507 0.81 CYP19A1 (0.47) CYP19A1CYP26A1CYP3A4ALDH1A1MAPT
SCHEMBL9728699 0.79 KCNQ2 (0.41) CYP3A4CYP2D6CYP2C9ALDH1A1MAPT
SCHEMBL9235863 0.78 CYP19A1 (0.55) CYP19A1CYP26A1CYP3A4CYP2C8CYP2D6
SCHEMBL9524535 0.78 CYP19A1 (0.53) CYP19A1CYP26A1CYP3A4CYP2C8CYP2D6
SCHEMBL8917818 0.76 CYP19A1 (0.55) CYP19A1CYP26A1CYP3A4CYP2C8CYP2D6
SCHEMBL10581964 0.75 CYP19A1 (0.55) CYP19A1CYP26A1CYP3A4ALDH1A1MAPT
SCHEMBL9190598 0.75 CYP26A1 (0.44) CYP19A1CYP26A1ALDH1A1MAPTPKM
SCHEMBL30468324 0.74 PKM (0.64) ALDH1A1MAPTTHRBPKMPOLB
SCHEMBL9652287 0.74 PKM (0.64) ALDH1A1MAPTTHRBPKMPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1036003-C A process for preparing (1H-azol-1-ylmethyl) substituted quinoxaline derivatives JANSSEN PHARMACEUTICA NV (BE) 1997-10-01 CN disclosed
CN-1033752-C (1H-azol-1-ylmethyl) substituted quinoline or quinolinone derivatives JANSSEN PHARMACEUTICA NV (SE) 1997-01-08 CN disclosed
CN-1106004-A A process for preparing (1H-azol-1-ylmethyl) substituted quinazoline derivatives JANSSEN PHARMACEUTICA NV (BE) 1995-08-02 CN disclosed
CN-1106005-A A process for preparing (1H-azol-1-ylmethyl) substituted quinoxaline derivatives JANSSEN PHARMACEUTICA NV (BE) 1995-08-02 CN disclosed
EP-0371564-B1 (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives JANSSEN PHARMACEUTICA NV (BE) 1995-07-12 EP disclosed
US-5151421-A Compounds for inhibition of metabolism of retinoids, for treatment for proliferation of epithelial cells and keratin disorders JANSSEN PHARMACEUTICA N.V. (BE) 1992-09-29 US disclosed
US-5028606-A Retinoid metabolism inhibitors JANSSEN PHARMACEUTICA N.V. (BE) 1991-07-02 US disclosed
CN-1042912-A (1H-oxazol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives JANSSEN PHARMACEUTICA NV (BE) 1990-06-13 CN disclosed
EP-0371564-A2 (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1990-06-06 EP disclosed