Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 14/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.53 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9235863 | 0.84 | CYP19A1 (0.55) | CYP19A1CYP26A1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL9192569 | 0.78 | CYP19A1 (0.46) | CYP19A1CYP26A1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL9523782 | 0.77 | CYP19A1 (0.60) | CYP19A1CYP26A1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL9523472 | 0.75 | CYP19A1 (0.60) | CYP19A1CYP26A1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL20390016 | 0.74 | CYP26A1 (0.50) | CYP19A1CYP26A1CYP3A4ALDH1A1 | |
| SCHEMBL20390004 | 0.74 | ALDH1A1 (0.52) | CYP19A1CYP26A1CYP24A1ALDH1A1 | |
| SCHEMBL14092698 | 0.74 | CYP19A1 (0.63) | CYP19A1CYP26A1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL8917077 | 0.73 | CYP19A1 (0.63) | CYP19A1CYP26A1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL9191682 | 0.73 | CYP19A1 (0.62) | CYP19A1CYP26A1CYP3A4ALDH1A1CYP11B1 | |
| SCHEMBL10581964 | 0.72 | CYP19A1 (0.55) | CYP19A1CYP26A1CYP3A4ALDH1A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293978-B1 | (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-09-15 | — | — | EP | disclosed |
| US-5039677-A | Estrogen inhibitor | JANSSEN PHARMACEUTICA N.V. (CA) | 1991-08-13 | — | — | US | disclosed |
| US-4943574-A | AROMATASE INHIBITORS, ESTROGEN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |
| EP-0293978-A2 | (1H-azol-1-ylmethyl)substituted benzotriazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-07 | — | — | EP | disclosed |