Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Carbon Monoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 6/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.32 |
| ▸ | BAD | Q92934 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NQO1 | P15559 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCND1 | P24385 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29924184 | 0.92 | DRD1 (0.39) | CES1DRD1PARP1CYP3A4TDP1 | |
| SCHEMBL665033 | 0.92 | DRD1 (0.39) | CES1DRD1PARP1CYP3A4TDP1 | |
| SCHEMBL29424782 | 0.92 | DRD1 (0.39) | CES1DRD1PARP1CYP3A4TDP1 | |
| Iodide SCHEMBL9231386 | 0.91 | DRD1 (0.38) | CES1DRD1PARP1CYP3A4TDP1 | |
| Iodide SCHEMBL9231383 | 0.91 | DRD1 (0.38) | CES1DRD1PARP1CYP3A4TDP1 | |
| SCHEMBL9192628 | 0.91 | DRD1 (0.38) | CES1DRD1PARP1CYP3A4TDP1 | |
| Hydrochloric Acid SCHEMBL9191831 | 0.90 | DRD1 (0.37) | CES1DRD1CYP3A4TDP1KIF11 | |
| SCHEMBL14356045 | 0.89 | DRD1 (0.39) | CES1DRD1PARP1CYP3A4TDP1 | |
| SCHEMBL26550837 | 0.88 | DRD1 (0.38) | CES1DRD1PARP1CYP3A4TDP1 | |
| Acetic Acid SCHEMBL30315806 | 0.87 | DRD1 (0.37) | CES1DRD1METAP2BCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0479542-B1 | A phosphino binaphthyl compound and transition metal complexes thereof | TAKASAGO PERFUMERY CO LTD (JP) | 1995-11-29 | — | — | EP | disclosed |
| US-5206399-A | 2,2'-BIS(DIPHENYLPHOSPHINO)-5,5',6,6',7,7',8,8'-OCTAHYDRO-1,1'-BINAPHTHYL AND TRANSITION METAL COMPLEX CONTAINING THE SAME AS LIGAND | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1993-04-27 | — | — | US | disclosed |
| EP-0479542-A1 | A phosphino binaphthyl compound and transition metal complexes thereof | Takasago International Corporation (JP) | 1992-04-08 | — | — | EP | disclosed |