Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9194242 | 0.90 | TP53 (0.46) | SMN1; SMN2KMT2AMEN1HTTKCNE1 | |
| SCHEMBL9199615 | 0.89 | ABCB1 (0.39) | HTTKCNE1KCNQ1KDM4EALDH1A1 | |
| SCHEMBL9195978 | 0.86 | ABCB1 (0.56) | ABCB1 | |
| SCHEMBL9193746 | 0.86 | POLB (0.44) | KDM4EALDH1A1LMNAABCB1BRD4 | |
| SCHEMBL9197650 | 0.86 | MAPT (0.41) | KMT2AMEN1LMNAABCB1MAPT | |
| SCHEMBL9198469 | 0.85 | ABCC9 (0.40) | KMT2AMEN1KDM4EALDH1A1BRD4 | |
| SCHEMBL9194983 | 0.83 | MAPT (0.44) | SMN1; SMN2KDM4EALDH1A1LMNABRD4 | |
| SCHEMBL9197589 | 0.79 | MAPT (0.43) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9200212 | 0.77 | KDM4E (0.48) | SMN1; SMN2KMT2AMEN1KCNE1KCNQ1 | |
| SCHEMBL9197632 | 0.77 | MAPT (0.42) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0406656-B1 | Chroman derivatives | MERCK PATENT GMBH (DE) | 1995-01-11 | — | — | EP | disclosed |
| US-5112839-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-05-12 | — | — | US | disclosed |
| EP-0406656-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-01-09 | — | — | EP | disclosed |