Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.46 |
| ▸ | ABCC9 | O60706 | 8/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.42 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195978 | 0.90 | ABCB1 (0.56) | ABCB1ABCC9CYP3A4ALOX15ABCC8 | |
| SCHEMBL9197589 | 0.87 | MAPT (0.43) | KDM4ESMN1; SMN2ALDH1A1HPGDGAA | |
| SCHEMBL9195596 | 0.85 | ABCC9 (0.52) | KDM4EABCB1ABCC9CYP3A4ALOX15 | |
| SCHEMBL9197632 | 0.84 | MAPT (0.42) | KDM4ESMN1; SMN2ALDH1A1HPGDGAA | |
| SCHEMBL9199695 | 0.84 | MAPT (0.41) | KDM4ESMN1; SMN2ABCC9LMNAMAPT | |
| SCHEMBL9681465 | 0.82 | ABCB1 (0.47) | ABCB1ABCC9CYP3A4ALOX15 | |
| SCHEMBL9680386 | 0.82 | ABCC9 (0.46) | KDM4EABCB1ABCC9CYP3A4ALOX15 | |
| SCHEMBL9192327 | 0.79 | ABCC9 (0.54) | KDM4EABCB1ABCC9CYP3A4ABCC8 | |
| SCHEMBL9274025 | 0.77 | ABCB1 (0.45) | ABCB1ABCC9CYP3A4ALOX15ABCC8 | |
| SCHEMBL9194242 | 0.77 | TP53 (0.46) | SMN1; SMN2ALDH1A1ABCB1ABCC9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0406656-B1 | Chroman derivatives | MERCK PATENT GMBH (DE) | 1995-01-11 | — | — | EP | disclosed |
| US-5112839-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-05-12 | — | — | US | disclosed |
| EP-0406656-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-01-09 | — | — | EP | disclosed |