Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TYR | P14679 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5692024 | 0.89 | HTT (0.43) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL9192220 | 0.89 | DHFR (0.42) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL201692 | 0.85 | NPC1 (0.57) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL9192801 | 0.84 | HTT (0.42) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL9192781 | 0.84 | HTT (0.42) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL9187478 | 0.83 | DHFR (0.41) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL6314093 | 0.83 | HTT (0.50) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL28031372 | 0.83 | NPC1 (0.55) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL28215541 | 0.83 | NPC1 (0.55) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL27977349 | 0.83 | NPC1 (0.55) | HTTNPC1HPGDMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0464844-B1 | Novel bis (4-(2,6-di-alkyl)phenol)silane derivatives as antiatherosclerotic agents and as antioxidants | MERRELL DOW PHARMA (US) | 1995-12-27 | — | — | EP | disclosed |
| US-5304668-A | Bis-[4-(2,6-di-alkyl)phenolisilane derivatives as antiatherosclerotic agents | MERRELL DOW PHARMACEUTICALS (US) | 1994-04-19 | — | — | US | disclosed |
| US-5281738-A | Anticholesterol agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0464844-A1 | Novel bis (4-(2,6-di-alkyl)phenol)silane derivatives as antiatherosclerotic agents and as antioxidants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-01-08 | — | — | EP | disclosed |