Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9275639 | 0.87 | GRM2 (0.35) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7352500 | 0.81 | PDE10A (0.51) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9700106 | 0.80 | PDE10A (0.47) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7374155 | 0.78 | MAPK14 (0.60) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9297762 | 0.76 | MAPK14 (0.52) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9195347 | 0.76 | MAPK14 (0.55) | MAPK13MAPK12MAPK11MAPK14KDM4E | |
| SCHEMBL9277096 | 0.75 | MAPK14 (0.56) | MAPK13MAPK12MAPK11MAPK14KDM4E | |
| SCHEMBL7381635 | 0.75 | TEK (0.44) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9197222 | 0.74 | GABRA1 (0.36) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9271797 | 0.73 | MAPK14 (0.38) | MAPK13MAPK12MAPK11MAPK14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563286-A4 | NOVEL CSAIDS | SMITHKLINE BEECHAM CORP (US) | 1995-01-11 | — | — | EP | claimed |
| EP-0563286-A1 | NOVEL CSAIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-06 | — | — | EP | claimed |
| WO-1992010498-A1 | NOVEL CSAIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-06-25 | — | — | WO | claimed |
| EP-0563286-A4 | NOVEL CSAIDS | SMITHKLINE BEECHAM CORP (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0563286-A1 | NOVEL CSAIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-06 | — | — | EP | disclosed |
| WO-1992010498-A1 | NOVEL CSAIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-06-25 | — | — | WO | disclosed |