Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.55 |
| ▸ | GCGR | P47871 | 5/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9275627 | 0.86 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL9277096 | 0.85 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7381635 | 0.84 | TEK (0.44) | MAPK14MAPK13MAPK12MAPK11TEK | |
| SCHEMBL9271797 | 0.82 | MAPK14 (0.38) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7352490 | 0.79 | PDE10A (0.60) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7377231 | 0.79 | PDE10A (0.60) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL9700092 | 0.78 | PDE10A (0.56) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL9195358 | 0.76 | GABRA1 (0.42) | MAPK14MAPK13MAPK12MAPK11PDE10A | |
| SCHEMBL7369791 | 0.75 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7374151 | 0.75 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563286-A4 | NOVEL CSAIDS | SMITHKLINE BEECHAM CORP (US) | 1995-01-11 | — | — | EP | claimed |
| EP-0563286-A1 | NOVEL CSAIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-06 | — | — | EP | claimed |
| WO-1992010498-A1 | NOVEL CSAIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-06-25 | — | — | WO | claimed |
| EP-0563286-A4 | NOVEL CSAIDS | SMITHKLINE BEECHAM CORP (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0563286-A1 | NOVEL CSAIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-06 | — | — | EP | disclosed |
| WO-1992010498-A1 | NOVEL CSAIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-06-25 | — | — | WO | disclosed |