Hydrogen Sulfide

Hydrogen Sulfide

SCHEMBL9195473

Clc1ccccc1-c1ccccc1Cl.Clc1ccccc1-c1ccccc1Cl.Clc1ccccc1-c1ccccc1Cl.Clc1ccccc1-c1ccccc1Cl.S.S

nearest known ligand 0.63

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.63
LMNA P02545 2/20 0.60
TSHR P16473 2/20 0.60
DPP4 P27487 1/20 0.56
NPC1 O15118 2/20 0.52
RAB9A P51151 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
HPGD P15428 2/20 0.52
TP53 P04637 1/20 0.52
PTPRC P08575 1/20 0.50
POLB P06746 1/20 0.48
KMT2A Q03164 1/20 0.48
PLA2G7 Q13093 1/20 0.48
ALDH1A1 P00352 4/20 0.48
HSD11B1 P28845 1/20 0.48
IDO1 P14902 2/20 0.46
NOTUM Q6P988 1/20 0.44
LDHA P00338 1/20 0.44
KDM4E B2RXH2 2/20 0.43
DCUN1D1 Q96GG9 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrogen Sulfide SCHEMBL8574751 1.00 CYP2A6 (0.63) CYP2A6LMNATSHRDPP4NPC1
SCHEMBL29802156 0.96 CYP2A6 (0.67) CYP2A6LMNATSHRDPP4NPC1
SCHEMBL671133 0.96 CYP2A6 (0.67) CYP2A6LMNATSHRDPP4NPC1
SCHEMBL29883244 0.96 CYP2A6 (0.67) CYP2A6LMNATSHRDPP4NPC1
Ammonia Solution, Strong SCHEMBL735046 0.93 CYP2A6 (0.63) CYP2A6LMNATSHRDPP4NPC1
Ethyne SCHEMBL9861738 0.90 CYP2A6 (0.60) CYP2A6LMNATSHRDPP4NPC1
SCHEMBL10794320 0.84 CYP2A6 (0.55) CYP2A6LMNATSHRDPP4NPC1
Hydrogen Sulfide SCHEMBL27800861 0.84 CYP2A6 (0.76) CYP2A6LMNATSHRDPP4NPC1
Hydrogen Sulfide SCHEMBL9316585 0.82 CYP2A6 (0.94) CYP2A6LMNATSHRDPP4NPC1
Hydrogen Sulfide SCHEMBL9191135 0.82 CYP2A6 (0.94) CYP2A6LMNATSHRDPP4NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5153305-A From diaryl disulfide; mild conditions using organometallic catalyst RESEARCH INSTITUTE FOR PRODUCTION DEVELOPMENT (JP) 1992-10-06 US claimed
CN-111116461-B Palladium-catalyzed o-toluidine amide gamma-C- (sp)3) Synthesis method of H sulfur/selenium ether compound 浙江工业大学 2021-07-27 CN disclosed
CN-111116461-A Palladium-catalyzed o-toluidine amide gamma-C- (sp)3) Synthesis method of H sulfur/selenium ether compound 浙江工业大学 2020-05-08 CN disclosed
EP-0402481-B1 PRODUCTION OF POLYARYLENE THIOETHER PROD DEV RES INST (JP) 1995-10-25 EP disclosed
US-5290911-A Forming polymers by catalytic oxidative coupling RESEARCH INSTITUTE FOR PRODUCTION DEVELOPMENT (JP) 1994-03-01 US disclosed
US-5153305-A From diaryl disulfide; mild conditions using organometallic catalyst RESEARCH INSTITUTE FOR PRODUCTION DEVELOPMENT (JP) 1992-10-06 US disclosed
US-4983720-A Process for preparing a polyarylene thioether IDEMITSU PETROCHEMICAL CO., LTD. (JP) 1991-01-08 US disclosed
EP-0402481-A1 PRODUCTION OF POLYARYLENE THIOETHER RESEARCH INSTITUTE FOR PRODUCTION DEVELOPMENT (JP) 1990-12-19 EP disclosed
US-4931542-A Process for preparing a polyarylene thioether IDEMITSU PETROCHEMICAL COMPANY, LIMITED (JP) 1990-06-05 US disclosed
EP-0281036-A2 A process for preparing a polyarylene thioether IDEMITSU PETROCHEMICAL CO. LTD. (JP) 1988-09-07 EP disclosed