Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.78 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.78 |
| ▸ | SLC6A9 | P48067 | 9/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17549671 | 0.89 | SLC6A4 (0.78) | SLC6A4HRH3SLC6A9SLC6A2SLC6A3 | |
| SCHEMBL679320 | 0.88 | SLC6A4 (1.00) | SLC6A4HRH3SLC6A9SLC6A2SLC6A3 | |
| SCHEMBL29700710 | 0.88 | SLC6A4 (1.00) | SLC6A4HRH3SLC6A9SLC6A2SLC6A3 | |
| SCHEMBL9197766 | 0.85 | SLC6A4 (0.71) | SLC6A4HRH3SLC6A9SLC6A2SLC6A3 | |
| SCHEMBL8971668 | 0.83 | SLC6A4 (0.69) | SLC6A4HRH3SLC6A9SLC6A2SLC6A3 | |
| Oxalic Acid SCHEMBL4740319 | 0.83 | SLC6A4 (0.72) | SLC6A4HRH3SLC6A9CYP2D6CYP2C9 | |
| Oxalic Acid SCHEMBL7317614 | 0.82 | SLC6A4 (0.88) | SLC6A4HRH3SLC6A9SLC6A2SLC6A3 | |
| SCHEMBL5270870 | 0.81 | SLC6A4 (0.70) | SLC6A4HRH3SLC6A9SLC6A2 | |
| SCHEMBL7433161 | 0.81 | SLC6A4 (0.69) | SLC6A4HRH3SLC6A9SLC6A2SLC6A3 | |
| SCHEMBL17278117 | 0.80 | SLC7A5 (0.76) | SLC6A4HRH3SLC6A9SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399504-B1 | Aryloxyphenylpropylamines their preparation and use | NOVO NORDISK AS (DK) | 1995-05-03 | — | — | EP | disclosed |
| US-5310756-A | Aryloxyphenylpropylamines and their calcium overload blocking compositions and methods of use | NOVO NORDISK A/S (DK) | 1994-05-10 | — | — | US | disclosed |
| US-5145870-A | Treating calcium overload in brain cells, anoxia, migraine, ischemia, epilepsy, neurodegenerative diseases | NOVO NORDISK A/S (DK) | 1992-09-08 | — | — | US | disclosed |
| EP-0399504-A2 | Aryloxyphenylpropylamines their preparation and use | NOVO NORDISK A/S (DK) | 1990-11-28 | — | — | EP | disclosed |