Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 9/20 | 0.52 |
| ▸ | CNR2 | P34972 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.43 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28109945 | 0.85 | PLK1 (0.67) | PLK1HCAR3PLK3 | |
| SCHEMBL2913206 | 0.84 | HCAR3 (0.48) | PLK1CNR2KDM4EGLAL3MBTL1 | |
| SCHEMBL3396257 | 0.84 | KDM4E (0.52) | PLK1CNR2KDM4EGLAL3MBTL1 | |
| SCHEMBL9194517 | 0.84 | ABL1 (0.47) | KDM4EGLACNR1 | |
| SCHEMBL8715959 | 0.84 | CNR2 (0.58) | CNR2KDM4EGLAGAAALDH1A1 | |
| SCHEMBL11991449 | 0.82 | PTGER4 (0.51) | KDM4EGLAL3MBTL1GAAALDH1A1 | |
| SCHEMBL5928710 | 0.81 | KDM4E (0.69) | CNR2KDM4EGLAGAAALDH1A1 | |
| SCHEMBL15635588 | 0.80 | KDM4E (0.46) | CNR2KDM4EGLAL3MBTL1GAA | |
| SCHEMBL12723401 | 0.80 | RIPK1 (0.47) | KDM4EGLAL3MBTL1GAAALDH1A1 | |
| SCHEMBL10362908 | 0.80 | MAPT (0.57) | PLK1KDM4EL3MBTL1GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0425921-B1 | Benzimidazole derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5250554-A | Cardiovascular disorders | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-05 | — | — | US | disclosed |
| US-5128356-A | Angiotensin antagonist; cardiovascular disorders | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-07-07 | — | — | US | disclosed |
| EP-0425921-A1 | Benzimidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-05-08 | — | — | EP | disclosed |