Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9196127 | 0.91 | NPC1 (0.51) | NPC1POLBMEN1KMT2AUSP2 | |
| SCHEMBL9700353 | 0.89 | SMN1; SMN2 (0.53) | MEN1KMT2ACHRM5SMN1; SMN2HTT | |
| SCHEMBL9701796 | 0.89 | CHRM5 (0.45) | NPC1POLBCHRM5MAPTSMN1; SMN2 | |
| SCHEMBL9701757 | 0.89 | MAPT (0.45) | NPC1POLBMEN1KMT2ACHRM5 | |
| SCHEMBL9700630 | 0.86 | CHRM5 (0.47) | NPC1CHRM5MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL9204008 | 0.86 | LMNA (0.47) | NPC1POLBMEN1KMT2AUSP2 | |
| SCHEMBL9701775 | 0.86 | TP53 (0.41) | NPC1POLBMEN1KMT2ACHRM5 | |
| SCHEMBL9199720 | 0.85 | CHRM5 (0.41) | NPC1POLBMEN1KMT2ACHRM5 | |
| SCHEMBL9196766 | 0.82 | SLC6A2 (0.34) | NPC1POLBMEN1KMT2AUSP2 | |
| SCHEMBL9204759 | 0.82 | SLC6A3 (0.40) | NPC1POLBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682523-A1 | USE OF TRICYCLIC ISOINDOLINONES AS ANTIVIRAL DRUGS, AND NEW, OPTICALLY ACTIVE ISOINDOLINONES | Roche Diagnostics GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |
| WO-1992015310-A1 | USE OF TRICYCLIC ISOINDOLINONES AS ANTIVIRAL DRUGS, AND NEW, OPTICALLY ACTIVE ISOINDOLINONES | BOEHRINGER MANNHEIM GMBH (DE) | 1992-09-17 | — | — | WO | disclosed |