Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.45 |
| ▸ | ITGAV | P06756 | 7/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9194455 | 0.95 | SLC6A2 (0.63) | SLC6A2ITGB3ITGAVSRD5A2ROCK1 | |
| SCHEMBL8845725 | 0.83 | SLC6A2 (0.54) | SLC6A2ITGB3ITGAVITGB5NPC1 | |
| SCHEMBL9193611 | 0.81 | SLC6A2 (0.54) | SLC6A2ITGB3ITGAVMEN1NPC1 | |
| SCHEMBL9201002 | 0.80 | SLC6A2 (0.43) | SLC6A2SRD5A2ROCK1HDAC1HDAC6 | |
| SCHEMBL8845716 | 0.80 | SLC6A2 (0.55) | SLC6A2ITGB3ITGAVITGB5MEN1 | |
| SCHEMBL9197969 | 0.79 | SLC6A2 (0.65) | SLC6A2ITGB3ITGAVROCK1 | |
| SCHEMBL9196762 | 0.79 | SLC6A2 (0.40) | SLC6A2SRD5A2MEN1NPC1RAB9A | |
| SCHEMBL9198615 | 0.79 | SLC6A2 (0.59) | SLC6A2ITGB3ITGAVITGB5MEN1 | |
| SCHEMBL8845539 | 0.79 | SLC6A2 (0.56) | SLC6A2ITGB3ITGAVITGB5 | |
| SCHEMBL9500100 | 0.78 | SLC6A2 (0.44) | SLC6A2MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0471296-B1 | 1-(Pyridinylalkyl)-1H-indoles, indolines and related analogs | HOECHST ROUSSEL PHARMA (US) | 1995-11-08 | — | — | EP | disclosed |
| US-5214058-A | Acetylcholinesterase inhibitors, treatment of senile dementia | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0471296-A1 | 1-(Pyridinylalkyl)-1H-indoles, indolines and related analogs | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-02-19 | — | — | EP | disclosed |