Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.51 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.51 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.51 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.51 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.51 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9345715 | 0.83 | PRKAA2 (0.66) | DRD3PRKAA2POLBGAAMEN1 | |
| SCHEMBL517897 | 0.80 | PRKAA2 (0.80) | PRKAA2POLBGAAMEN1KMT2A | |
| SCHEMBL15302927 | 0.78 | PRKAA2 (0.61) | PRKAA2POLBGAAMEN1KMT2A | |
| SCHEMBL518286 | 0.77 | PRKAA2 (0.69) | PRKAA2MEN1KMT2AKCNH2PRKAB2 | |
| SCHEMBL518526 | 0.74 | PRKAA2 (0.71) | PRKAA2MEN1KMT2AKCNH2PRKAB2 | |
| SCHEMBL25284686 | 0.74 | DRD2 (0.75) | DRD3POLBGAAMEN1KMT2A | |
| SCHEMBL25239004 | 0.72 | PKM (0.78) | DRD3GAAMEN1KMT2AKCNH2 | |
| SCHEMBL10284370 | 0.72 | PRKAA2 (0.59) | PRKAA2POLBGAAMEN1KMT2A | |
| SCHEMBL9197096 | 0.72 | P4HTM (0.53) | POLBMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL9200180 | 0.72 | HPGD (0.52) | PRKAA2POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0278452-B1 | 2,4- and 2,5-Pyridine-dicarboxylic-acid derivatives, process for their preparation, their use and medicines based on these compounds | HOECHST AG (DE) | 1995-05-24 | — | — | EP | disclosed |