Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 6/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HK1 | P19367 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9914796 | 0.85 | HSD17B1 (0.59) | HSD17B1HSD17B2PRKDCRAB9AALDH1A1 | |
| SCHEMBL12700852 | 0.83 | HSD17B1 (0.57) | HSD17B1HSD17B2PRKDCRAB9AALDH1A1 | |
| SCHEMBL1773393 | 0.82 | SNCA (0.50) | SNCAHSD17B1HSD17B2RAB9AALDH1A1 | |
| SCHEMBL28530288 | 0.80 | SNCA (0.50) | SNCAHSD17B1HSD17B2ALDH1A1MAPT | |
| SCHEMBL1817967 | 0.80 | CNR1 (0.44) | HSD17B1HSD17B2PRKDCRAB9AALDH1A1 | |
| SCHEMBL5014032 | 0.80 | SNCA (0.50) | SNCAHSD17B1HSD17B2RAB9AALDH1A1 | |
| SCHEMBL2778388 | 0.79 | SNCA (0.61) | SNCARAB9AALDH1A1MAPTHPGD | |
| SCHEMBL10717919 | 0.78 | HSD17B1 (0.50) | SNCAHSD17B1HSD17B2RAB9AALDH1A1 | |
| SCHEMBL3329598 | 0.78 | RAB9A (0.52) | SNCAHSD17B1HSD17B2RAB9AALDH1A1 | |
| SCHEMBL4340111 | 0.77 | SNCA (0.59) | SNCAHSD17B1HSD17B2RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656900-A4 | CATIONIC-2-HETEROARYLPHENYL-CARBAPENEM ANTIBACTERIAL AGENTS. | MERCK & CO INC (US) | 1995-09-06 | — | — | EP | disclosed |
| EP-0656900-A1 | CATIONIC-2-HETEROARYLPHENYL-CARBAPENEM ANTIBACTERIAL AGENTS | MERCK & CO. INC. (US) | 1995-06-14 | — | — | EP | disclosed |
| US-5342933-A | Cationic-2-heteroarylphenyl-carbapenem antibacterial agents | MERCK & CO., INC. (US) | 1994-08-30 | — | — | US | disclosed |
| WO-1994005669-A1 | CATIONIC-2-HETEROARYLPHENYL-CARBAPENEM ANTIBACTERIAL AGENTS | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| US-5292879-A | Intermediates for preparing cationic-2-heteroaryl-phenyl-carbapenem antibacterial agents | MERCK & CO., INC. (US) | 1994-03-08 | — | — | US | disclosed |
| US-5220011-A | Antibiotics effective against resistant grampositive bacteria | MERCK & CO., INC. (US) | 1993-06-15 | — | — | US | disclosed |
| EP-0520553-A1 | 2-Heteroarylphenyl-carbapenem antibacterial agents | MERCK & CO. INC. (US) | 1992-12-30 | — | — | EP | disclosed |
| US-5143914-A | 2-heteroarylphenyl-carbapenem antibacterial agents | MERCK & CO., INC. (US) | 1992-09-01 | — | — | US | disclosed |