SCHEMBL9196865

SCHEMBL9196865

Oc1ccc2nc(-c3ccc(Cl)cc3Cl)oc2c1

nearest known ligand 0.68

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 18/20 0.68
ESR2 Q92731 18/20 0.68
KDM6B O15054 1/20 0.48
KDM6A O15550 1/20 0.48
APEX1 P27695 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14409198 0.92 ESR1 (0.77) ESR1ESR2KDM6BKDM6A
SCHEMBL9511231 0.89 PIK3CG (0.54) ESR1ESR2APEX1
SCHEMBL4035485 0.88 ESR1 (0.86) ESR1ESR2KDM6BKDM6A
SCHEMBL10385204 0.82 MAPT (0.53) ESR1ESR2KDM6BKDM6AAPEX1
SCHEMBL1378442 0.81 ESR1 (1.00) ESR1ESR2KDM6BKDM6A
SCHEMBL12704759 0.81 TTR (0.66) ESR1ESR2APEX1
SCHEMBL1377583 0.80 ESR1 (1.00) ESR1ESR2KDM6BKDM6A
SCHEMBL2248809 0.80 ESR1 (0.81) ESR1ESR2
SCHEMBL7573646 0.80 NPC1 (0.56) ESR1ESR2KDM6BKDM6A
SCHEMBL16815259 0.80 ESR1 (0.60) ESR1ESR2KDM6BKDM6A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0422252-B1 Method for detecting a substance using chemiluminescence TORAY INDUSTRIES (JP) 1995-07-26 EP disclosed
US-5206149-A Reaction of peroxidase, oxidant, luminol and 2-hydroxy-9-fluorenone enhancer; chemiluminescence TORAY INDUSTRIES, INC. (JP) 1993-04-27 US disclosed
EP-0422252-A1 Method for detecting a substance using chemiluminescence TORAY INDUSTRIES, INC. (JP) 1991-04-17 EP disclosed