Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 8/20 | 0.64 |
| ▸ | AGTR1 | P30556 | 7/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.58 |
| ▸ | EDNRA | P25101 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7054450 | 0.88 | AGTR2 (0.71) | AGTR2AGTR1HDAC1HDAC6PPARG | |
| SCHEMBL9687841 | 0.87 | AGTR1 (0.72) | AGTR2AGTR1HDAC1HDAC6PPARG | |
| SCHEMBL9123025 | 0.79 | AGTR1 (1.00) | AGTR2AGTR1PPARG | |
| SCHEMBL9275378 | 0.78 | AGTR1 (0.78) | AGTR2AGTR1PPARG | |
| SCHEMBL9087920 | 0.78 | AGTR1 (0.76) | AGTR2AGTR1PPARG | |
| SCHEMBL8394993 | 0.78 | AGTR2 (0.76) | AGTR2AGTR1PPARG | |
| SCHEMBL7591162 | 0.77 | AGTR2 (0.62) | AGTR2AGTR1PPARG | |
| SCHEMBL8396220 | 0.76 | AGTR1 (0.77) | AGTR2AGTR1PPARG | |
| SCHEMBL9197881 | 0.75 | AGTR1 (1.00) | AGTR2AGTR1PPARG | |
| SCHEMBL8394534 | 0.75 | PPARG (0.77) | AGTR2AGTR1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399732-B1 | Benzimidazole derivatives | ZENECA LTD (GB) | 1995-07-26 | — | — | EP | claimed |
| US-5171748-A | For hypertension, cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-12-15 | — | — | US | disclosed |