Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL994096 | 0.83 | CYP11B2 (0.53) | CYP11B2CYP11B1PDE3BPDE3AHTR1A | |
| SCHEMBL5985192 | 0.81 | CYP11B2 (0.55) | CYP11B2CYP11B1PDE3BPDE3AHTR1A | |
| SCHEMBL30336213 | 0.80 | CYP11B2 (0.53) | CYP11B2CYP11B1PDE3BPDE3AHTR1A | |
| SCHEMBL22077625 | 0.80 | CYP11B2 (0.53) | CYP11B2CYP11B1PDE3BPDE3AHTR1A | |
| SCHEMBL3331324 | 0.80 | CYP11B2 (0.53) | CYP11B2CYP11B1PDE3BPDE3AHTR1A | |
| SCHEMBL9411106 | 0.80 | CYP11B2 (0.53) | CYP11B2CYP11B1PDE3BPDE3AHTR1A | |
| SCHEMBL15059383 | 0.80 | CYP11B2 (0.53) | CYP11B2CYP11B1PDE3BPDE3AHTR1A | |
| SCHEMBL520359 | 0.80 | CYP11B2 (0.53) | CYP11B2CYP11B1PDE3BPDE3AHTR1A | |
| SCHEMBL12101220 | 0.80 | CYP11B2 (0.53) | CYP11B2CYP11B1PDE3BPDE3AHTR1A | |
| SCHEMBL8146771 | 0.80 | CYP11B2 (0.50) | CYP11B2CYP11B1PDE3BPDE3AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030668-A1 | CYCLIC ETHER DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | ZENECA LIMITED (GB) | 1995-11-16 | — | — | WO | disclosed |
| EP-0462813-B1 | Bicyclic pyran derivatives and their use as inhibitors of 5-lipoxygenase | ZENECA LTD (GB) | 1995-10-25 | — | — | EP | disclosed |
| US-5373007-A | Lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5321025-A | Inhibitors of 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-06-14 | — | — | US | disclosed |
| US-5217969-A | Antiinflammatory, antiulcer agent | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |
| EP-0485111-A2 | The use of lipoxygenase and cyclooxygenase inhibitors as synergistic agents | ZENECA LIMITED (GB) | 1992-05-13 | — | — | EP | disclosed |
| EP-0462813-A2 | Bicyclic pyran derivatives and their use as inhibitors of 5-lipoxygenase | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |