Sugi Predict

Sugi Predict / Compounds / SCHEMBL520359

SCHEMBL520359

SCHEMBL520359

CN1C(=O)COc2cc(N)ccc21

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP11B2 P19099 2/20 0.53
▸ CYP11B1 P15538 1/20 0.53
▸ PDE3B Q13370 2/20 0.48
▸ PDE3A Q14432 2/20 0.48
▸ HTR1A P08908 4/20 0.43
▸ HTR2C P28335 3/20 0.43
▸ GABRA5 P31644 3/20 0.42
▸ GABRA1 P14867 1/20 0.42
▸ IDH1 O75874 1/20 0.41
▸ GABRG2 P18507 2/20 0.40
▸ GABRB3 P28472 2/20 0.40
▸ F10 P00742 1/20 0.39
▸ SYK P43405 1/20 0.39
▸ HTR1D P28221 1/20 0.39
▸ HTR1B P28222 1/20 0.39
▸ SLC6A4 P31645 1/20 0.39
▸ KCNH2 Q12809 1/20 0.39
▸ ALOX5 P09917 1/20 0.39
▸ ATAD2 Q6PL18 1/20 0.39
▸ GRM4 Q14833 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31481226 1.00 CYP11B2 (0.53) CYP11B2CYP11B1PDE3BPDE3AHTR1A
SCHEMBL30991588 0.87 PDE3B (0.51) CYP11B2CYP11B1PDE3BPDE3AHTR1A
SCHEMBL653919 0.87 PDE3B (0.51) CYP11B2CYP11B1PDE3BPDE3AHTR1A
SCHEMBL5985192 0.81 CYP11B2 (0.55) CYP11B2CYP11B1PDE3BPDE3AHTR1A
SCHEMBL9437724 0.80 HTR1A (0.55) CYP11B2CYP11B1PDE3BPDE3AHTR1A
SCHEMBL16522709 0.80 CHRM1 (0.47) ATAD2
SCHEMBL3331324 0.80 CYP11B2 (0.53) CYP11B2CYP11B1PDE3BPDE3AHTR1A
SCHEMBL22077625 0.80 CYP11B2 (0.53) CYP11B2CYP11B1PDE3BPDE3AHTR1A
SCHEMBL9199243 0.80 CYP11B2 (0.53) CYP11B2CYP11B1PDE3BPDE3AHTR1A
SCHEMBL12101220 0.80 CYP11B2 (0.53) CYP11B2CYP11B1PDE3BPDE3AHTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 199 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110230478-A1 4-Alkyl-substituted diaminopyrimidines Bayer ScienceCrop AG (DE) 2011-09-22 — — US claimed
EP-2330904-A2 4-ALKYL-SUBSTITUTED DIAMINOPYRIMIDINES Bayer CropScience AG (DE) 2011-06-15 — — EP claimed
US-20110105472-A1 Diaminopyrimidines as crop protection agents BAYER CROPSCIENCE AG (DE) 2011-05-05 — — US claimed
US-20100081679-A1 DIAMINOPYRIMIDINES AS FUNGICIDES BAYER CROPSCIENCE AG (DE) 2010-04-01 — — US claimed
WO-2010025863-A2 4-ALKYL-SUBSTITUTED DIAMINOPYRIMIDINES BAYER CROPSCIENCE AG (DE) 2010-03-11 — — WO claimed
EP-2161259-A1 4-Haloalkyl substituted Diaminopyrimidine Bayer CropScience AG (DE) 2010-03-10 — — EP claimed
CN-101621927-A Diaminopyrimidines as fungicides BAYER CROPSCIENCE AG 2010-01-06 — — CN claimed
EP-2129222-A1 DIAMINOPYRIMIDINES AS FUNGICIDES Bayer CropScience AG (DE) 2009-12-09 — — EP claimed
WO-2008107096-A1 DIAMINOPYRIMIDINES AS FUNGICIDES BAYER CROPSCIENCE AG (DE) 2008-09-12 — — WO claimed
US-20040147760-A1 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives PHARMACIA & UPJOHN COMPANY 2004-07-29 — — US claimed
EP-4719391-A2 TRIPLE KINASE INHIBITORS Unogen Biotech Ltd. (US) 2026-04-08 — — EP disclosed
US-20260085050-A1 TRIPLE KINASE INHIBITORS UNOGEN BIOTECH LTD (US) 2026-03-26 — — US disclosed
WO-2024249831-A2 TRIPLE KINASE INHIBITORS UNOGEN BIOTECH LTD. (US) 2024-12-05 — — WO disclosed
US-20240327393-A1 FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2024-10-03 — — US disclosed
CN-117999259-A Iron death modulators, their preparation and use 维泰瑞隆有限公司 2024-05-07 — — CN disclosed
WO-1999037641-A1 NOVEL BICYCLENE-SUBSTITUTED OXAZOLIDINONES BAYER AKTIENGESELLSCHAFT (DE) 1999-07-29 — — WO disclosed
EP-0548254-B1 6- OR 7-(IMIDAZOLIDIN-2-YLIDENEAMINO)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS ALLERGAN INC (US) 1999-06-02 — — EP disclosed
EP-0548254-A1 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS ALLERGAN, INC. (US) 1993-06-30 — — EP disclosed
WO-1992004345-A1 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS ALLERGAN, INC. (US) 1992-03-19 — — WO disclosed
US-5091528-A Antiglaucoma, antidiarrhea agents, diuretics, vasoconstrictors ALLERGAN, INC. (US) 1992-02-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260085050-A1 TRIPLE KINASE INHIBITORS ALK, ERBB2, ERBB3 CYP11B2 2596/4885CYP11B1 2310/4885PDE3B 3812/4885
US-20040147760-A1 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives OXA1L, AADAC, MT-ND5 CYP11B2 2413/4885CYP11B1 3456/4885PDE3B 2354/4885
US-20240327393-A1 FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF AIFM2, GPX1, GPX4 CYP11B2 210/4885CYP11B1 229/4885PDE3B 3051/4885
US-20100081679-A1 DIAMINOPYRIMIDINES AS FUNGICIDES PM20D2, DDT, DDX41 CYP11B2 2140/4885CYP11B1 1491/4885PDE3B 266/4885
US-20110230478-A1 4-Alkyl-substituted diaminopyrimidines DPM1, DPYD, POLR1C CYP11B2 3591/4885CYP11B1 3053/4885PDE3B 631/4885
US-20110105472-A1 Diaminopyrimidines as crop protection agents DDX41, DDX1, DDX5 CYP11B2 4008/4885CYP11B1 3210/4885PDE3B 436/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.