SCHEMBL9199593

SCHEMBL9199593

COc1cccc(Cn2ccc3cc(OCc4ccc5ccccc5n4)ccc32)c1

nearest known ligand 0.67

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CYSLTR1 Q9Y271 5/20 0.56
GPBAR1 Q8TDU6 4/20 0.56
ALOX5 P09917 1/20 0.53
CYSLTR2 Q9NS75 2/20 0.53
ALOX5AP P20292 3/20 0.49
PDE10A Q9Y233 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8616407 0.86 CYSLTR1 (0.66) CYSLTR1GPBAR1ALOX5CYSLTR2ALOX5AP
SCHEMBL8617516 0.85 CYSLTR1 (0.64) CYSLTR1GPBAR1ALOX5CYSLTR2
SCHEMBL8588067 0.85 CYSLTR1 (0.53) CYSLTR1GPBAR1ALOX5CYSLTR2ALOX5AP
SCHEMBL9202041 0.85 ALOX5AP (0.55) CYSLTR1GPBAR1ALOX5CYSLTR2ALOX5AP
SCHEMBL9205037 0.84 ALOX5AP (0.55) CYSLTR1GPBAR1CYSLTR2ALOX5APPDE10A
SCHEMBL9565378 0.82 GPBAR1 (0.50) CYSLTR1GPBAR1ALOX5CYSLTR2PDE10A
SCHEMBL9199864 0.82 CYSLTR1 (0.60) CYSLTR1GPBAR1CYSLTR2ALOX5AP
SCHEMBL8538241 0.81 CYSLTR1 (0.67) CYSLTR1GPBAR1ALOX5CYSLTR2ALOX5AP
SCHEMBL9199452 0.81 GPBAR1 (0.59) CYSLTR1GPBAR1CYSLTR2PDE10A
SCHEMBL10547803 0.81 CYSLTR1 (0.69) CYSLTR1GPBAR1ALOX5CYSLTR2PDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0544821-B1 INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS PFIZER (US) 1995-01-11 EP claimed
US-5290788-A Indole derivatives as antiallergy and antiinflammatory agents PFIZER INC. (US) 1994-03-01 US claimed
EP-0544821-A1 INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. PFIZER (US) 1993-06-09 EP claimed
WO-1992006088-A1 INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS PFIZER INC. (US) 1992-04-16 WO claimed
JP-4145079-A None JP disclosed
EP-0544821-B1 INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS PFIZER (US) 1995-01-11 EP disclosed
US-5290788-A Indole derivatives as antiallergy and antiinflammatory agents PFIZER INC. (US) 1994-03-01 US disclosed
EP-0544821-A1 INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. PFIZER (US) 1993-06-09 EP disclosed
JP-H04145079-A INDOLE DERIVATIVE AND USE THEREOF PFIZER PHARMACEUT CO LTD 1992-05-19 JP disclosed
WO-1992006088-A1 INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS PFIZER INC. (US) 1992-04-16 WO disclosed