Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.60 |
| ▸ | ALOX5AP | P20292 | 7/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540124 | 0.94 | CYSLTR1 (0.60) | CYSLTR1ALOX5APCYSLTR2HDAC11HDAC8 | |
| SCHEMBL8543705 | 0.90 | CYSLTR1 (0.61) | CYSLTR1ALOX5APCYSLTR2HDAC11HDAC8 | |
| SCHEMBL9203135 | 0.90 | CYSLTR1 (0.65) | CYSLTR1GPBAR1 | |
| SCHEMBL8616407 | 0.89 | CYSLTR1 (0.66) | CYSLTR1ALOX5APCYSLTR2GPBAR1 | |
| SCHEMBL8539273 | 0.87 | GPBAR1 (0.65) | CYSLTR1ALOX5APCYSLTR2GPBAR1 | |
| SCHEMBL8538241 | 0.85 | CYSLTR1 (0.67) | CYSLTR1ALOX5APCYSLTR2GPBAR1 | |
| SCHEMBL9202041 | 0.85 | ALOX5AP (0.55) | CYSLTR1ALOX5APCYSLTR2GPBAR1 | |
| SCHEMBL9199593 | 0.82 | CYSLTR1 (0.56) | CYSLTR1ALOX5APCYSLTR2GPBAR1 | |
| SCHEMBL8538239 | 0.82 | GPBAR1 (0.67) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8538620 | 0.82 | HDAC6 (0.56) | CYSLTR1ALOX5APCYSLTR2HDAC11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-B1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1995-01-11 | — | — | EP | disclosed |
| US-5290788-A | Indole derivatives as antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1994-03-01 | — | — | US | disclosed |
| EP-0544821-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. | PFIZER (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992006088-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-04-16 | — | — | WO | disclosed |