Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 19/20 | 0.67 |
| ▸ | DRD2 | P14416 | 18/20 | 0.67 |
| ▸ | HTR1A | P08908 | 8/20 | 0.53 |
| ▸ | HTR7 | P34969 | 6/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.53 |
| ▸ | DRD1 | P21728 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | DRD5 | P21918 | 2/20 | 0.53 |
| ▸ | HTR1D | P28221 | 2/20 | 0.53 |
| ▸ | HTR1B | P28222 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | HRH1 | P35367 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.53 |
| ▸ | HTR6 | P50406 | 2/20 | 0.53 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7283232 | 0.86 | DRD2 (0.72) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL23696404 | 0.83 | DRD2 (0.75) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL7323722 | 0.81 | DRD2 (0.75) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL23696403 | 0.80 | HTR2A (1.00) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL27678555 | 0.80 | DRD2 (0.44) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL7697170 | 0.80 | DRD2 (0.53) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL23696620 | 0.79 | HTR2A (0.69) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL12786171 | 0.77 | DRD2 (0.53) | HTR2ADRD2HTR1AKCNH2HTR2C | |
| SCHEMBL9772524 | 0.77 | DRD2 (0.51) | HTR2ADRD2HTR1AKCNH2HTR2C | |
| SCHEMBL8807852 | 0.77 | HTR2A (0.54) | HTR2ADRD2HTR1AHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353821-B1 | Antipsychotic 3-piperazinyl-benzazole derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-05-10 | — | — | EP | disclosed |
| US-5015740-A | Psychological disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-05-14 | — | — | US | disclosed |
| US-4957916-A | DISORDERS CONNECTED WITH DOPAMINE AND/OR SEROTONIN RELEASE | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-09-18 | — | — | US | disclosed |
| EP-0353821-A2 | Antipsychotic 3-piperazinyl-benzazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-02-07 | — | — | EP | disclosed |