Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.53 |
| ▸ | HTR2A | P28223 | 12/20 | 0.53 |
| ▸ | HTR1A | P08908 | 6/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.53 |
| ▸ | DRD1 | P21728 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | DRD5 | P21918 | 2/20 | 0.53 |
| ▸ | HTR1D | P28221 | 2/20 | 0.53 |
| ▸ | HTR1B | P28222 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | HRH1 | P35367 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7283232 | 0.86 | DRD2 (0.72) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| SCHEMBL7703857 | 0.82 | DRD2 (0.51) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| SCHEMBL7701569 | 0.82 | HTR2C (0.61) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| SCHEMBL7699932 | 0.82 | DRD2 (0.55) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| SCHEMBL9492109 | 0.82 | DRD2 (0.51) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| SCHEMBL7323722 | 0.81 | DRD2 (0.75) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| SCHEMBL9202999 | 0.81 | DRD2 (0.51) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| SCHEMBL9199749 | 0.80 | HTR2A (0.67) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| SCHEMBL7700609 | 0.77 | HTR2C (0.47) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| SCHEMBL9276925 | 0.76 | DRD2 (0.56) | DRD2HTR2AHTR1AKCNH2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6348457-B1 | ANTAGONIZING RESERPINE IN MAMMALS | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-02-19 | — | — | US | disclosed |
| EP-0672043-B1 | NOVEL 4-(3-BENZOFURANYL)PIPERIDINYL AND 4-(3-BENZOTHIENYL)PIPERIDINYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JANSSEN PHARMACEUTICA NV (BE) | 2001-05-30 | — | — | EP | disclosed |