Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 9/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.43 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.42 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195596 | 0.86 | ABCC9 (0.52) | ABCC9CYP3A4ALOX15ABCC8KCNJ11 | |
| SCHEMBL9195978 | 0.82 | ABCB1 (0.56) | ABCC9CYP3A4ALOX15ABCC8KCNJ11 | |
| SCHEMBL9200212 | 0.82 | KDM4E (0.48) | ABCC9CYP3A4ALOX15ABCC8KCNJ11 | |
| SCHEMBL9192327 | 0.80 | ABCC9 (0.54) | ABCC9CYP3A4ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9681465 | 0.72 | ABCB1 (0.47) | ABCC9CYP3A4ALOX15ABCB1 | |
| SCHEMBL9199659 | 0.72 | KDM4E (0.45) | ABCC9CYP3A4ALOX15ABCC8KCNJ11 | |
| SCHEMBL9192434 | 0.71 | KCNA5 (0.39) | ABCC9KDM4E | |
| SCHEMBL9193528 | 0.71 | ABCB1 (0.52) | ABCC9CYP3A4ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9197878 | 0.71 | ABCC9 (0.37) | ABCC9CYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9197672 | 0.70 | ABCB1 (0.43) | ABCC9CYP3A4ALOX15ABCC8KCNJ11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112839-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-05-12 | — | — | US | disclosed |
| EP-0406656-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-01-09 | — | — | EP | disclosed |