Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9209068 | 0.83 | CYSLTR1 (0.53) | — | |
| SCHEMBL27016499 | 0.82 | KDM4E (0.60) | ALDH1A1HPGDKDM4EHSD17B10CYP1A2 | |
| SCHEMBL710398 | 0.81 | KDM4E (0.73) | ALDH1A1HPGDKDM4EHSD17B10CYP1A2 | |
| SCHEMBL18886838 | 0.80 | ALDH1A1 (0.61) | ALDH1A1HPGDKDM4EHSD17B10CYP1A2 | |
| SCHEMBL853412 | 0.80 | GAA (0.46) | ALDH1A1HPGDKDM4EHSD17B10PDGFRB | |
| SCHEMBL1464939 | 0.79 | HPGD (0.53) | ALDH1A1HPGDKDM4EHSD17B10SRD5A2 | |
| SCHEMBL951355 | 0.78 | ALDH1A1 (0.59) | ALDH1A1HPGDKDM4EHSD17B10CYP1A2 | |
| SCHEMBL7431714 | 0.78 | MEN1 (0.63) | ALDH1A1HPGDKDM4EHSD17B10CYP1A2 | |
| SCHEMBL951357 | 0.78 | ALDH1A1 (0.59) | ALDH1A1HPGDKDM4EHSD17B10CYP1A2 | |
| SCHEMBL6219955 | 0.77 | TRPM8 (0.60) | ALDH1A1HPGDKDM4ELMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-B1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1995-01-11 | — | — | EP | disclosed |
| US-5290788-A | Indole derivatives as antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1994-03-01 | — | — | US | disclosed |