Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.39 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9200647 | 1.00 | CCKBR (0.52) | CCKBRTP53DRD4SLC6A12SLC6A13 | |
| SCHEMBL9200663 | 1.00 | CCKBR (0.52) | CCKBRTP53DRD4SLC6A12SLC6A13 | |
| SCHEMBL9205770 | 0.87 | CCKBR (0.46) | CCKBR | |
| SCHEMBL9205759 | 0.87 | CCKBR (0.46) | CCKBR | |
| SCHEMBL9205749 | 0.87 | CCKBR (0.46) | CCKBR | |
| SCHEMBL9205875 | 0.86 | CCKBR (0.54) | CCKBRDRD4SLC6A12SLC6A13 | |
| SCHEMBL9205881 | 0.86 | CCKBR (0.54) | CCKBRDRD4SLC6A12SLC6A13 | |
| SCHEMBL9205891 | 0.86 | CCKBR (0.54) | CCKBRDRD4SLC6A12SLC6A13 | |
| SCHEMBL9276303 | 0.86 | HPGDS (0.48) | CCKBR | |
| SCHEMBL9276291 | 0.86 | HPGDS (0.48) | CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0561941-B1 | N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS | SEARLE & CO (US) | 1995-01-04 | — | — | EP | claimed |
| EP-0561941-A1 | N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS. | SEARLE & CO (US) | 1993-09-29 | — | — | EP | claimed |
| WO-1992010476-A1 | N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS | G.D. SEARLE & CO. (US) | 1992-06-25 | — | — | WO | claimed |
| EP-0561941-B1 | N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS | SEARLE & CO (US) | 1995-01-04 | — | — | EP | disclosed |
| US-5314886-A | N-substituted lactams useful as cholecystokinin antagonists | G. D. SEARLE & CO. (US) | 1994-05-24 | — | — | US | disclosed |
| EP-0561941-A1 | N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS. | SEARLE & CO (US) | 1993-09-29 | — | — | EP | disclosed |
| EP-0555331-A1 | N-SUBSTITUTED IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS. | SEARLE & CO (US) | 1993-08-18 | — | — | EP | disclosed |
| US-5202344-A | Disorders of the gastrointestinal, central nervous system and appetite regulatory systems | G. D. SEARLE & CO. (US) | 1993-04-13 | — | — | US | disclosed |