Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10796898 | 0.82 | CYP11B2 (0.42) | ALDH1A1 | |
| SCHEMBL3602750 | 0.81 | S100A9 (0.40) | LRRK2MCL1KDM4EALDH1A1GAA | |
| SCHEMBL9042765 | 0.81 | LRRK2 (0.49) | LRRK2MCL1KDM4EALDH1A1GAA | |
| SCHEMBL12670740 | 0.81 | CHUK (0.43) | KDM4EALDH1A1GAAHPGDMEN1 | |
| SCHEMBL11937872 | 0.80 | ERBB2 (0.44) | LRRK2MCL1KDM4EALDH1A1LMNA | |
| SCHEMBL29765 | 0.80 | LRRK2 (0.46) | LRRK2MCL1KDM4EALDH1A1LMNA | |
| SCHEMBL10504897 | 0.79 | KDM4E (0.54) | LRRK2KDM4EALDH1A1LMNAGAA | |
| SCHEMBL12677388 | 0.78 | IKBKB (0.48) | XDH | |
| SCHEMBL11937863 | 0.77 | PDE3B (0.47) | LRRK2KDM4ELMNAHPGDXDH | |
| SCHEMBL10852761 | 0.77 | KDM4E (0.46) | MCL1KDM4ELMNAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1932833-B1 | NITROGENATED HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KISSEI PHARMACEUTICAL (JP) | 2012-08-01 | — | — | EP | disclosed |
| US-7947707-B2 | Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2011-05-24 | — | — | US | disclosed |
| US-7947707-B2 | Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2011-05-24 | — | — | US | disclosed |
| US-20090306396-A1 | NITROGENATED HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-12-10 | — | — | US | disclosed |
| US-20090306396-A1 | NITROGENATED HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-12-10 | — | — | US | disclosed |
| EP-1932833-A1 | NITROGENATED HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Kissei Pharmaceutical Co., Ltd. (JP) | 2008-06-18 | — | — | EP | disclosed |
| EP-0378046-B1 | Process for the preparation of 3-phenyl-pyrrole derivatives | CIBA GEIGY AG (CH) | 1995-01-18 | — | — | EP | disclosed |
| US-4958030-A | Process for the preparation of 3-phenylpyrrole derivatives | CIBA-GEIGY CORPORATION (US) | 1990-09-18 | — | — | US | disclosed |
| EP-0378046-A1 | Process for the preparation of 3-phenyl-pyrrole derivatives | CIBA-GEIGY AG (CH) | 1990-07-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306396-A1 | NITROGENATED HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | XDH, CBR3, CBR1 | LRRK2 1460/4885MCL1 3972/4885KDM4E 3294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.