Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 5/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195135 | 0.93 | MAP4K4 (0.40) | NR1I2P2RX7MAPTPIK3CAMTOR | |
| SCHEMBL1562375 | 0.91 | MAPT (0.43) | MAPTPIK3CAMTORMEN1KMT2A | |
| SCHEMBL18291297 | 0.88 | PTGER4 (0.46) | NR1I2PIK3CAMTORPTGER4GLS | |
| SCHEMBL9200293 | 0.85 | NR1I2 (0.40) | NR1I2MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9197797 | 0.82 | CYP11B2 (0.48) | NR1I2MAPTPIK3CAMTORMEN1 | |
| SCHEMBL9195108 | 0.81 | PDE10A (0.44) | NR1I2PIK3CAMTORMEN1KMT2A | |
| SCHEMBL2146739 | 0.80 | PDE10A (0.56) | MAPTPIK3CAMTORIRAK4PDE10A | |
| SCHEMBL2146743 | 0.80 | PDE10A (0.56) | MAPTPIK3CAMTORIRAK4PDE10A | |
| SCHEMBL2146811 | 0.80 | PDE10A (0.56) | MAPTPIK3CAMTORIRAK4PDE10A | |
| SCHEMBL18291295 | 0.80 | NR1I2 (0.46) | NR1I2KMT2APTGER4PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0435381-B1 | Antipicornaviral pyridazinamines | JANSSEN PHARMACEUTICA NV (BE) | 1995-11-02 | — | — | EP | disclosed |
| US-5196535-A | Viricides | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-23 | — | — | US | disclosed |
| US-5100893-A | Viricides, effective against picorna virus, durability | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-03-31 | — | — | US | disclosed |
| EP-0435381-A1 | Antipicornaviral pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-07-03 | — | — | EP | disclosed |