Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1562360 | 0.91 | MAPT (0.43) | NR1I2MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9198687 | 0.85 | CHRNB2 (0.53) | MAPTCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9200650 | 0.85 | NR1I2 (0.40) | NR1I2MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9214199 | 0.82 | OGA (0.39) | NR1I2MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL18291297 | 0.82 | PTGER4 (0.46) | NR1I2GLSMAP4K4 | |
| SCHEMBL9193256 | 0.81 | HTT (0.41) | NR1I2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9195135 | 0.79 | MAP4K4 (0.40) | NR1I2MAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9196230 | 0.79 | OPRK1 (0.37) | NR1I2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9216360 | 0.77 | CYP1A2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3KMT2A | |
| SCHEMBL25059012 | 0.76 | SMN1; SMN2 (0.41) | NR1I2MAPTKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1037268-C | Antipicornaviral pyridazinamines | JANSSEM PHARMACEUTICA N V (BE) | 1998-02-04 | — | — | CN | disclosed |
| EP-0435381-B1 | Antipicornaviral pyridazinamines | JANSSEN PHARMACEUTICA NV (BE) | 1995-11-02 | — | — | EP | disclosed |
| US-5196535-A | Viricides | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-23 | — | — | US | disclosed |
| US-5100893-A | Viricides, effective against picorna virus, durability | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-03-31 | — | — | US | disclosed |
| CN-1052857-A | The preparation method of the pyridazine amine that antipicornaviral is used | JANSSEN PHARMACEUTICA NV (BE) | 1991-07-10 | — | — | CN | disclosed |
| EP-0435381-A1 | Antipicornaviral pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-07-03 | — | — | EP | disclosed |