Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9194560 | 0.88 | PTGER1 (0.48) | PTGER2HRH1ALDH1A1ALOX15KMT2A | |
| SCHEMBL9194995 | 0.87 | SIRT1 (0.49) | HRH1P2RX4 | |
| SCHEMBL9200681 | 0.78 | MEN1 (0.46) | PARP1PARP2PTGER2ALDH1A1ALOX15 | |
| SCHEMBL9198859 | 0.77 | MEN1 (0.48) | PTGER2HRH1ALDH1A1ALOX15KMT2A | |
| SCHEMBL9175557 | 0.75 | MEN1 (0.51) | PTGER2P2RX4ALDH1A1ALOX15KMT2A | |
| SCHEMBL7838597 | 0.74 | PTGER2 (0.42) | PTGER2P2RX4ALDH1A1SIGMAR1KDM4E | |
| SCHEMBL9368290 | 0.73 | ALDH1A1 (0.46) | P2RX4ALDH1A1SIGMAR1KDM4EKMT2A | |
| SCHEMBL1366170 | 0.73 | HDAC6 (0.61) | KCNH2 | |
| SCHEMBL1367376 | 0.73 | HDAC6 (0.58) | PTGER2 | |
| SCHEMBL9192861 | 0.72 | PTGER4 (0.45) | PTGER4PTGER2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0480641-B1 | Tricyclic heterocycles | ZENECA LTD (GB) | 1995-04-05 | — | — | EP | disclosed |
| US-5189033-A | Analgesics, antiiflammatory agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-23 | — | — | US | disclosed |
| EP-0480641-A1 | Tricyclic heterocycles | ZENECA LIMITED (GB) | 1992-04-15 | — | — | EP | disclosed |