Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9200737 | 1.00 | NPC1 (0.42) | NPC1CASP3ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL9203728 | 0.85 | NPC1 (0.46) | NPC1CASP3ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL9205895 | 0.81 | MEN1 (0.45) | NPC1CASP3ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL9205900 | 0.81 | MEN1 (0.45) | NPC1CASP3ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL9200012 | 0.78 | NPC1 (0.36) | NPC1CASP3ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL9200007 | 0.78 | NPC1 (0.36) | NPC1CASP3ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL9209946 | 0.71 | NPC1 (0.44) | NPC1CASP3ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL9207807 | 0.71 | NPC1 (0.44) | NPC1CASP3ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL9209950 | 0.71 | NPC1 (0.44) | NPC1CASP3ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL8814165 | 0.69 | ALDH1A1 (0.44) | CASP3ALDH1A1KMT2AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0561941-B1 | N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS | SEARLE & CO (US) | 1995-01-04 | — | — | EP | disclosed |
| US-5314886-A | N-substituted lactams useful as cholecystokinin antagonists | G. D. SEARLE & CO. (US) | 1994-05-24 | — | — | US | disclosed |
| US-5202344-A | Disorders of the gastrointestinal, central nervous system and appetite regulatory systems | G. D. SEARLE & CO. (US) | 1993-04-13 | — | — | US | disclosed |
| WO-1992010476-A1 | N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS | G.D. SEARLE & CO. (US) | 1992-06-25 | — | — | WO | disclosed |